Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10999
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dc.contributor.authorChételat, Gaël-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorBourgeat, Pierrick-
dc.contributor.authorPike, Kerryn E-
dc.contributor.authorJones, Gareth-
dc.contributor.authorAmes, David-
dc.contributor.authorEllis, Kathryn A-
dc.contributor.authorSzoeke, Cassandra-
dc.contributor.authorMartins, Ralph N-
dc.contributor.authorO'Keefe, Graeme J-
dc.contributor.authorSalvado, Olivier-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorRowe, Christopher C-
dc.date.accessioned2015-05-16T00:34:41Z
dc.date.available2015-05-16T00:34:41Z
dc.date.issued2010-03-01-
dc.identifier.citationAnnals of Neurology; 67(3): 317-24en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10999en
dc.description.abstractElucidating the role of aggregated beta-amyloid in relation to gray matter atrophy is crucial to the understanding of the pathological mechanisms of Alzheimer disease and for the development of therapeutic trials. The present study aims to assess this relationship.Brain magnetic resonance imaging and [(11)C]Pittsburgh compound B (PiB)-positron emission tomography scans were obtained from 94 healthy elderly subjects (49 with subjective cognitive impairment), 34 patients with mild cognitive impairment, and 35 patients with Alzheimer disease. The correlations between global and regional neocortical PiB retention and atrophy were analyzed in each clinical group.Global and regional atrophy were strongly related to beta-amyloid load in participants with subjective cognitive impairment but not in patients with mild cognitive impairment or Alzheimer disease. Global neocortical beta-amyloid deposition correlated to atrophy in a large brain network including the hippocampus, medial frontal and parietal areas, and lateral temporoparietal cortex, whereas regional beta-amyloid load was related to local atrophy in the areas of highest beta-amyloid load only, that is, medial orbitofrontal and anterior and posterior cingulate/precuneus areas.There is a strong relationship between beta-amyloid deposition and atrophy very early in the disease process. As the disease progresses to mild cognitive impairment and Alzheimer disease clinical stages, pathological events other than, and probably downstream from, aggregated beta-amyloid deposition might be responsible for the ongoing atrophic process. These findings suggest that antiamyloid therapy should be administered very early in the disease evolution to minimize synaptic and neuronal loss.en
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherAged, 80 and overen
dc.subject.otherAlzheimer Disease.metabolism.pathology.radionuclide imagingen
dc.subject.otherAmyloid beta-Peptides.analysis.metabolismen
dc.subject.otherAtrophy.metabolism.pathology.radionuclide imagingen
dc.subject.otherBenzothiazoles.diagnostic useen
dc.subject.otherBiological Markers.analysis.metabolismen
dc.subject.otherBrain.metabolism.pathology.radionuclide imagingen
dc.subject.otherCognition Disorders.metabolism.pathology.radionuclide imagingen
dc.subject.otherDisease Progressionen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMagnetic Resonance Imagingen
dc.subject.otherMaleen
dc.subject.otherPlaque, Amyloid.metabolism.pathology.radionuclide imagingen
dc.subject.otherPositron-Emission Tomographyen
dc.subject.otherPredictive Value of Testsen
dc.subject.otherPrognosisen
dc.subject.otherSeverity of Illness Indexen
dc.titleRelationship between atrophy and beta-amyloid deposition in Alzheimer disease.en
dc.typeJournal Articleen
dc.identifier.journaltitleAnnals of Neurologyen
dc.identifier.affiliationchetelate@cyceron.fren
dc.identifier.affiliationDepartment of Nuclear Medicine and Center for PET, Austin Health, 145 Studley Road, Heidelberg, Victoria 3084, Australiaen
dc.identifier.doi10.1002/ana.21955en
dc.description.pages317-24en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/20373343en
dc.contributor.corpauthorAustralian Imaging Biomarkers and Lifestyle Research Groupen
dc.type.contentTexten
dc.type.austinJournal Articleen
local.name.researcherMasters, Colin L
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptMolecular Imaging and Therapy-
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