Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10978
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dc.contributor.authorSong, Ken
dc.contributor.authorAllen, A Men
dc.contributor.authorPaxinos, Gen
dc.contributor.authorMendelsohn, Frederick AOen
dc.date.accessioned2015-05-16T00:33:24Z
dc.date.available2015-05-16T00:33:24Z
dc.date.issued1991-02-01en
dc.identifier.citationClinical and Experimental Pharmacology & Physiology; 18(2): 93-6en
dc.identifier.govdoc2022083en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10978en
dc.description.abstract1. Angiotensin II (AII) receptor binding was localized in the rat brain by in vitro autoradiography using the antagonist analogue, 125I-[Sar1, Ile8] AII. AII receptor binding was then differentiated into type I and type II subtypes by displacement with unlabelled non-peptide antagonists specific for AII subtypes. 2. Type I binding was determined as that inhibited by Dup753 (10 mumol/L) and type II binding as that inhibited by XD329-1 (10 mumol/L). The reducing agent dithiothreitol (DTT) decreased the binding to type I receptors and enhanced the binding to type II receptors. 3. Structures such as the vascular organ of the lamina terminalis, subfornical organ, median preoptic nucleus, area postrema, nucleus of the solitary tract, which are known to be related to some central actions of AII, contain exclusively type I AII receptors. 4. In contrast, the locus coeruleus, ventral and dorsal parts of lateral septum, superior colliculus, subthalamic nucleus, some nuclei of the thalamus, and the nuclei of the inferior olive contain predominantly type II AII receptors. 5. These results reveal important pharmacological heterogeneity of brain AII receptors which suggest different regional functions and are relevant to the central actions of emerging classes of new non-peptide AII receptor antagonists.en
dc.language.isoenen
dc.subject.other1-Sarcosine-8-Isoleucine Angiotensin II.diagnostic useen
dc.subject.otherAnimalsen
dc.subject.otherAutoradiographyen
dc.subject.otherBrain.metabolismen
dc.subject.otherIn Vitro Techniquesen
dc.subject.otherMaleen
dc.subject.otherRadioligand Assayen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred Strainsen
dc.subject.otherReceptors, Angiotensin.analysisen
dc.titleAngiotensin II receptor subtypes in rat brain.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical and Experimental Pharmacology & Physiologyen
dc.identifier.affiliationDepartment of Medicine, Austin Hospital, University of Melbourne, Heidelberg, Victoria, Australiaen
dc.description.pages93-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2022083en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
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