Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10973
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dc.contributor.authorWang, Qingjuen
dc.contributor.authorAlén, Markkuen
dc.contributor.authorLyytikäinen, Arjaen
dc.contributor.authorXu, Leitingen
dc.contributor.authorTylavsky, Fran Aen
dc.contributor.authorKujala, Urho Men
dc.contributor.authorKröger, Heikkien
dc.contributor.authorSeeman, Egoen
dc.contributor.authorCheng, Sulinen
dc.date.accessioned2015-05-16T00:33:04Z
dc.date.available2015-05-16T00:33:04Z
dc.date.issued2010-07-01en
dc.identifier.citationJournal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research; 25(7): 1512-20en
dc.identifier.govdoc20200961en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10973en
dc.description.abstractFamilial resemblance and diversity in bone structure and strength in adulthood are determined in part during growth. Whether these characteristics are established during gestation or shortly after birth is not known. Total-body, lumbar spine, and femoral neck size and mass and indices of tibial bending strength and distal radial compressive strength were measured using bone densitometry and quantitative computed tomography in 236 girls at 18.5 years of age. Among them, 219, 141, and 105 girls had crown-heel length (CHL) and weight recorded at birth and at 6 and 12 months of age, and then height and weight were recorded at 3, 5, 10, 13, and 15 years of age in 181, 176, 127, 111, and 228 girls, respectively. Of these girls, 101 and 93 girls also had bone structure assessed at 11 and 13 years of age, respectively. Similar bone measurements were made once in 78 mother-father pairs. CHL and weight at birth did not correlate or did so weakly with bone traits in girls at 18 years of age. By contrast, CHL at 6 months correlated with the height, bone traits, and strength at puberty and at 18 years of age (r = 0.24-0.56, p < .001) in girls and with their parents' height and bone traits (r = 0.15-0.37, p < .05). When the girls' CHL at 6 months was stratified into quartiles, the absolute and relative differences in bone traits observed at puberty (approximately 11.5 years) were maintained as these traits tracked during the ensuing 7 years. Similarly, weight at 6 months correlated with the girls' bone traits at puberty and 18 years of age (r = 0.22-0.55, p < .05). During puberty and at 18 years of age, the girls' bone traits correlated with the corresponding traits in their parents (r = 0.32-0.43, p < .01). It is concluded that familial resemblance in bone structural strength and the position of an individual's bone traits relative to others in adulthood are likely to be established during the first year of life. Thus susceptibility to bone fragility late in life has its antecedents established early in life.en
dc.language.isoenen
dc.subject.otherAdolescenten
dc.subject.otherBone Densityen
dc.subject.otherBone and Bones.physiologyen
dc.subject.otherFamilyen
dc.subject.otherFemaleen
dc.subject.otherGrowth.physiologyen
dc.subject.otherHumansen
dc.subject.otherInfanten
dc.subject.otherInfant, Newbornen
dc.titleFamilial resemblance and diversity in bone mass and strength in the population are established during the first year of postnatal life.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Bone and Mineral Researchen
dc.identifier.affiliationEndocrine Centre, Austin Health, University of Melbourne, Melbourne, Australiaen
dc.identifier.doi10.1002/jbmr.45en
dc.description.pages1512-20en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/20200961en
dc.type.austinJournal Articleen
local.name.researcherSeeman, Ego
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptEndocrinology-
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