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dc.contributor.authorLy, J V-
dc.contributor.authorDonnan, Geoffrey A-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorZavala, J A-
dc.contributor.authorMa, Henry K-
dc.contributor.authorO'Keefe, Graeme J-
dc.contributor.authorGong, Sylvia J-
dc.contributor.authorGunawan, R M-
dc.contributor.authorSaunder, T-
dc.contributor.authorAckermann, Uwe-
dc.contributor.authorTochon-Danguy, Henri-
dc.contributor.authorChurilov, Leonid-
dc.contributor.authorPhan, T G-
dc.contributor.authorRowe, Christopher C-
dc.identifier.citationNeurology; 74(6): 487-93en
dc.description.abstractThe in vivo diagnosis of cerebral amyloid angiopathy (CAA) is inferred from clinical and structural imaging features. (11)C-Pittsburgh compound B (PIB) is a PET ligand that binds to beta-amyloid in extracellular plaques and vessel walls. We hypothesized that patients with a clinical diagnosis of CAA-related hemorrhage (CAAH) have increased (11)C-PIB uptake and that the pattern differs from Alzheimer disease (AD).Patients with CAAH based on established clinical criteria were studied using (11)C-PIB PET and were compared with age-matched controls and patients with AD. Distribution volume ratio (DVR) parametric maps were created using the cerebellar cortex as a reference region.Twelve patients with CAAH of mean age 73.9 (range 58-93) years were compared with 22 normal controls and 13 patients with AD of mean age 71.8 (59-83) and 73.8 (56-90) years, respectively. CAAH PIB median DVR binding was higher in cortical regions (1.69, interquartile range 1.44-1.97) compared with controls (1.32, 1.21-1.44, p = 0.002) but lower than AD (2.04, 1.93-2.26, p = 0.004). The occipital-global uptake ratio was lower among patients with AD than among patients with CAAH (p = 0.008), and the frontal-global uptake ratio was higher (p = 0.012).(11)C-Pittsburgh compound B (PIB) binding is moderately increased in most patients with probable cerebral amyloid angiopathy (CAA)-related intracerebral hemorrhage. The distribution may differ from that seen in Alzheimer disease. (11)C-PIB PET may assist in the in vivo diagnosis of CAA and serve as a surrogate marker for future therapeutic studies.en
dc.subject.otherAged, 80 and overen
dc.subject.otherBenzothiazoles.diagnostic use.metabolismen
dc.subject.otherCarbon Radioisotopes.diagnostic use.metabolismen
dc.subject.otherCerebral Amyloid Angiopathy.complications.radionuclide imagingen
dc.subject.otherHemorrhage.complications.radionuclide imagingen
dc.subject.otherMagnetic Resonance Imaging.methodsen
dc.subject.otherMental Status Scheduleen
dc.subject.otherMiddle Ageden
dc.subject.otherPositron-Emission Tomography.methodsen
dc.subject.otherProspective Studiesen
dc.subject.otherRetrospective Studiesen
dc.title11C-PIB binding is increased in patients with cerebral amyloid angiopathy-related hemorrhage.en
dc.typeJournal Articleen
dc.identifier.affiliationNational Stroke Research Institute, Level 1, Neurosciences Building, Austin Health, University of Melbourne, 300 Waterdale Rd., Heidelberg Heights, Victoria 3081, Australiaen
dc.type.austinJournal Articleen, Uwe
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.openairecristype Florey Institute of Neuroscience and Mental Health- Imaging and Therapy- Imaging and Therapy- (University of Melbourne)- Florey Institute of Neuroscience and Mental Health- Imaging and Therapy-
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