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https://ahro.austin.org.au/austinjspui/handle/1/10940
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seeman, Ego | en |
dc.contributor.author | Boonen, Steven | en |
dc.contributor.author | Borgström, Frederik | en |
dc.contributor.author | Vellas, Bruno | en |
dc.contributor.author | Aquino, Jean-Pierre | en |
dc.contributor.author | Semler, Jutta | en |
dc.contributor.author | Benhamou, Claude-Laurent | en |
dc.contributor.author | Kaufman, Jean-Marc | en |
dc.contributor.author | Reginster, Jean-Yves | en |
dc.date.accessioned | 2015-05-16T00:31:04Z | - |
dc.date.available | 2015-05-16T00:31:04Z | - |
dc.date.issued | 2009-12-21 | en |
dc.identifier.citation | Bone 2009; 46(4): 1038-42 | en |
dc.identifier.govdoc | 20026265 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/10940 | en |
dc.description.abstract | Longevity has resulted in a greater proportion of the population entering a time of life when increasing bone fragility and falls predispose to fractures, particularly nonvertebral fractures. Women over 80 years of age constitute 10% of the population but contribute 30% of all fractures and 60% of all nonvertebral fractures. Despite this, few studies have examined antifracture efficacy of treatments in this high-risk group and none has provided evidence for benefits beyond 3 years.To determine whether strontium ranelate reduces the risk of vertebral and nonvertebral fractures during 5 years, we analyzed a subgroup of 1489 female patients over 80 years of age (mean 83.5+/-3.0 years) with osteoporosis from the SOTI (spinal osteoporosis therapeutic intervention) and TROPOS (treatment of peripheral osteoporosis) studies randomized to strontium ranelate 2 g/d or placebo. All received a supplement of calcium plus vitamin D.By intention to treat, vertebral fracture risk was reduced by 31% (relative risk, RR=0.69; 95% confidence interval, CI 0.52-0.92), nonvertebral fracture risk by 27% (RR=0.73; 95% CI 0.57-0.95), major nonvertebral fracture risk by 33% (RR=0.67; 95% CI 0.50-0.89) and hip fracture risk by 24% (RR=0.76; 95% CI 0.50-1.15, not significant). Treatment was cost-saving as it decreased cost and increased QALYs and life-years.Strontium ranelate safely produced a significant reduction in vertebral and nonvertebral fracture risk during 5 years in postmenopausal women over 80 years of age and was cost saving. | en |
dc.language.iso | en | en |
dc.subject.other | Aged, 80 and over | en |
dc.subject.other | Bone Density.drug effects | en |
dc.subject.other | Bone Density Conservation Agents.therapeutic use | en |
dc.subject.other | Bone and Bones.drug effects | en |
dc.subject.other | Calcium, Dietary.therapeutic use | en |
dc.subject.other | Female | en |
dc.subject.other | Hip Fractures.prevention & control | en |
dc.subject.other | Humans | en |
dc.subject.other | Intention to Treat Analysis | en |
dc.subject.other | Organometallic Compounds.therapeutic use | en |
dc.subject.other | Osteoporosis, Postmenopausal.drug therapy | en |
dc.subject.other | Quality of Life | en |
dc.subject.other | Spinal Fractures.prevention & control | en |
dc.subject.other | Thiophenes.therapeutic use | en |
dc.subject.other | Treatment Outcome | en |
dc.title | Five years treatment with strontium ranelate reduces vertebral and nonvertebral fractures and increases the number and quality of remaining life-years in women over 80 years of age. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Bone | en |
dc.identifier.affiliation | Austin Health, University of Melbourne, Melbourne, Australia | en |
dc.identifier.doi | 10.1016/j.bone.2009.12.006 | en |
dc.description.pages | 1038-42 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/20026265 | en |
dc.type.austin | Journal Article | en |
local.name.researcher | Seeman, Ego | |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairetype | Journal Article | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Endocrinology | - |
Appears in Collections: | Journal articles |
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