Azad, Arun A; Chionh, Fiona; Scott, Andrew M; Lee, Szeting T; Berlangieri, Salvatore U; White, Shane C; Mitchell, Paul L R

doi:10.1007/s11307-009-0295-z

Author(s)

Azad, Arun A

Chionh, Fiona

Scott, Andrew M

Lee, Szeting T

Berlangieri, Salvatore U

White, Shane C

Mitchell, Paul L R

Publication Date

2009-11-17

Abstract

We evaluated whether 18F-FDG-PET altered stage classification, management, and prognostic stratification of newly diagnosed small cell lung cancer (SCLC).We identified 46 consecutive patients undergoing staging positron emission tomography for SCLC from 1993-2008 inclusive. Updated survival data from the state Cancer Registry was available on 42 of 46 patients.PET altered stage classification in 12 of 46 (26%) patients. PET altered treatment modality in nine patients, and the target mediastinal radiation field in another three patients. Therefore, PET altered management in 12 of 46 (26%) patients. Patients with limited disease (LD) on pre-PET staging had significantly longer overall survival (OS) than those upstaged to extensive disease (ED; median 18.6 months versus 5.7 months; log-rank p < 0.0001). In patients with ED on pre-PET staging, those downstaged to LD by PET had significantly longer OS than those with ED on PET (median 10.9 months versus 5.9 months; log-rank p = 0.037).PET had a major impact on stage classification, management, and prognostic stratification of newly diagnosed SCLC.

Citation

Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging 2009; 12(4): 443-51

Jornal Title

Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging

Link

https://ahro.austin.org.au/austinjspui/handle/1/10920

Title

High impact of 18F-FDG-PET on management and prognostic stratification of newly diagnosed small cell lung cancer.

Type of document

Journal Article

Austin Health

High impact of 18F-FDG-PET on management and prognostic stratification of newly diagnosed small cell lung cancer.

Files:

Author(s)	Azad, Arun A Chionh, Fiona Scott, Andrew M Lee, Szeting T Berlangieri, Salvatore U White, Shane C Mitchell, Paul L R
Publication Date	2009-11-17
Abstract	We evaluated whether 18F-FDG-PET altered stage classification, management, and prognostic stratification of newly diagnosed small cell lung cancer (SCLC).We identified 46 consecutive patients undergoing staging positron emission tomography for SCLC from 1993-2008 inclusive. Updated survival data from the state Cancer Registry was available on 42 of 46 patients.PET altered stage classification in 12 of 46 (26%) patients. PET altered treatment modality in nine patients, and the target mediastinal radiation field in another three patients. Therefore, PET altered management in 12 of 46 (26%) patients. Patients with limited disease (LD) on pre-PET staging had significantly longer overall survival (OS) than those upstaged to extensive disease (ED; median 18.6 months versus 5.7 months; log-rank p < 0.0001). In patients with ED on pre-PET staging, those downstaged to LD by PET had significantly longer OS than those with ED on PET (median 10.9 months versus 5.9 months; log-rank p = 0.037).PET had a major impact on stage classification, management, and prognostic stratification of newly diagnosed SCLC.
Citation	Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging 2009; 12(4): 443-51
Jornal Title	Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
Link	https://ahro.austin.org.au/austinjspui/handle/1/10920
Title	High impact of 18F-FDG-PET on management and prognostic stratification of newly diagnosed small cell lung cancer.
Type of document	Journal Article