Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10902
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dc.contributor.authorWoodward, Michael Men
dc.contributor.authorJacova, Claudiaen
dc.contributor.authorBlack, Sandra Een
dc.contributor.authorKertesz, Andrewen
dc.contributor.authorMackenzie, Ian Ren
dc.contributor.authorFeldman, Howarden
dc.date.accessioned2015-05-16T00:28:45Z
dc.date.available2015-05-16T00:28:45Z
dc.date.issued2010-07-01en
dc.identifier.citationInternational Journal of Geriatric Psychiatry; 25(7): 732-8en
dc.identifier.govdoc19823987en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10902en
dc.description.abstractIndividuals with a clinical diagnosis of Alzheimer's disease (AD) may have prominent features of executive dysfunction and language impairment as well as behavioral abnormalities early in the disease ('high frontality'). When this occurs differentiation from frontotemporal dementia (FTD) is difficult. It is hypothesized that AD patients with high frontality may have clinical and pathological features that distinguish them from less frontal AD patients.In a well-characterized cohort of people with cognitive impairment, we used the Frontal Behavioral Inventory (FBI) in an attempt to identify AD patients with prominent frontal features (high-FBI AD) and distinguish them from the remainder of AD patients (low-FBI AD).The 18 high-FBI AD patients were compared with the 26 FTD patients who had an FBI performed and the 53 other low FBI AD patients. The individual FBI items did not differ significantly between the FTD and the high-FBI AD patients, and the high FBI AD patients were more like the FTD patients than the other AD patients with respect to presence of a family history of AD, proportion with homozygous apolipoprotein E(4) status, disability as measured by the Disability Assessment for Dementia (DAD) Scale and the Functional Rating Scale (FRS) and neuropsychiatric impairment as measured by the Neuropsychiatric Inventory (NPI). Memory symptom duration was similar in the high FBI AD group compared to the low FBI AD group.There is a subgroup of AD patients with high frontality that can be clinically distinguished from the remainder of AD patients but which requires pathological verification.en
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherAlzheimer Disease.diagnosis.psychologyen
dc.subject.otherBehavioral Symptoms.etiologyen
dc.subject.otherCohort Studiesen
dc.subject.otherDiagnosis, Differentialen
dc.subject.otherDiscriminant Analysisen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherNeuropsychological Testsen
dc.titleDifferentiating the frontal variant of Alzheimer's disease.en
dc.typeJournal Articleen
dc.identifier.journaltitleInternational journal of geriatric psychiatryen
dc.identifier.affiliationAged and Residential Care, Heidelberg Repatriation Hospital, Heidelberg West, Australiaen
dc.identifier.doi10.1002/gps.2415en
dc.description.pages732-8en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/19823987en
dc.contributor.corpauthorACCORD investigator groupen
dc.type.austinJournal Articleen
local.name.researcherWoodward, Michael M
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.author.deptAged Care-
crisitem.author.deptGeriatric Medicine-
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