Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10878
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dc.contributor.authorLee, Darren-
dc.contributor.authorHaase, Michael-
dc.contributor.authorHaase-Fielitz, Anja-
dc.contributor.authorPaizis, Kathy-
dc.contributor.authorGoehl, Hermann-
dc.contributor.authorBellomo, Rinaldo-
dc.date.accessioned2015-05-16T00:27:21Z
dc.date.available2015-05-16T00:27:21Z
dc.date.issued2009-09-03-
dc.identifier.citationBlood Purification 2009; 28(4): 365-72en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10878en
dc.description.abstractHigh cut-off (HCO) membranes may increase beta(2)-microglobulin (beta2M) removal compared to standard high-flux membranes.Eight stable haemodialysis patients were enrolled in a prospective, randomized, double-blind, cross-over study and treated with HCO and high-flux membranes for 2 weeks each, between a 1-week washout period. Primary end point was serum beta2M removal. Secondary end points included serum albumin concentrations, albumin and small solute clearances.HCO membranes achieved significantly lower median post-dialysis beta2M concentration (10.8 vs. 14.2 mg/l; p = 0.003) and greater beta2M reduction ratio (62.3 vs. 51.0%; p < 0.002). Serum albumin decreased with HCO membranes (from 36 to 29.5 g/l; p = 0.018) but increased to 33.5 g/l after the washout period. Albumin clearance was significantly greater with HCO membranes (2.2 vs. 0.06 ml/min; p = 0.004). Urea reduction ratio was significantly lower with HCO membranes (64.8 vs. 71.5%; p < 0.001).beta2M removal was superior with HCO membranes. Reduction in serum albumin and lower small solute clearance require further investigations.en_US
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherCross-Over Studiesen
dc.subject.otherDouble-Blind Methoden
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMaterials Testingen
dc.subject.otherMembranes, Artificialen
dc.subject.otherMiddle Ageden
dc.subject.otherRenal Dialysis.instrumentationen
dc.subject.otherSerum Albumin.analysisen
dc.subject.otherTreatment Outcomeen
dc.subject.otherbeta 2-Microglobulin.blooden
dc.titleA pilot, randomized, double-blind, cross-over study of high cut-off versus high-flux dialysis membranes.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleBlood Purificationen_US
dc.identifier.affiliationNephrologyen_US
dc.identifier.doi10.1159/000235961en_US
dc.description.pages365-72en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/19729908en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherBellomo, Rinaldo
item.languageiso639-1en-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
crisitem.author.deptNephrology-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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