Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10857
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dc.contributor.authorBadawy, Radwa A Ben
dc.contributor.authorMacdonell, Richard A Len
dc.contributor.authorJackson, Graeme Den
dc.contributor.authorBerkovic, Samuel Fen
dc.date.accessioned2015-05-16T00:26:07Z
dc.date.available2015-05-16T00:26:07Z
dc.date.issued2009-07-21en
dc.identifier.citationNeurology; 73(3): 218-22en
dc.identifier.govdoc19620610en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10857en
dc.description.abstractWe used transcranial magnetic stimulation to investigate the effect of diurnal variability on cortical excitability in patients with epilepsy.Thirty drug-naive patients with epilepsy (20 idiopathic generalized epilepsy [IGE], including 10 juvenile myoclonic epilepsy [JME], and 10 focal epilepsy) and 10 control subjects without epilepsy were studied both early in the morning and late in the afternoon. We measured the mean motor thresholds and constructed recovery curves at short (2-15 msec) and long (50-400 msec) interstimulus intervals.An increase in cortical excitability indicated by decreased short and long intracortical inhibition was observed early in the morning compared to the afternoon in patients with JME. In other IGE syndromes, there was decreased long intracortical inhibition only. No effect was found in subjects with focal epilepsy or controls without epilepsy.Cortical excitability measured by transcranial magnetic stimulation increases early in the morning in patients with idiopathic generalized epilepsy, particularly in juvenile myoclonic epilepsy, but not in subjects with focal epilepsy or controls without epilepsy. This may explain the increased seizure susceptibility in this cohort at this time of day.en
dc.language.isoenen
dc.subject.otherAdolescenten
dc.subject.otherAdulten
dc.subject.otherCerebral Cortex.physiopathologyen
dc.subject.otherCircadian Rhythm.physiologyen
dc.subject.otherCohort Studiesen
dc.subject.otherDominance, Cerebral.physiologyen
dc.subject.otherEpilepsy.physiopathologyen
dc.subject.otherEpilepsy, Generalized.physiopathologyen
dc.subject.otherEvoked Potentials.physiologyen
dc.subject.otherEvoked Potentials, Motor.physiologyen
dc.subject.otherFemaleen
dc.subject.otherFunctional Laterality.physiologyen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherMyoclonic Epilepsy, Juvenile.physiopathologyen
dc.subject.otherNeural Inhibition.physiologyen
dc.subject.otherPredictive Value of Testsen
dc.subject.otherReaction Time.physiologyen
dc.subject.otherSleep.physiologyen
dc.subject.otherTranscranial Magnetic Stimulationen
dc.subject.otherWakefulness.physiologyen
dc.subject.otherYoung Adulten
dc.titleWhy do seizures in generalized epilepsy often occur in the morning?en
dc.typeJournal Articleen
dc.identifier.journaltitleNeurologyen
dc.identifier.affiliationDepartment of Neurology, Austin Health, Heidelberg, Victoria 3084, Australiaen
dc.identifier.doi10.1212/WNL.0b013e3181ae7ca6en
dc.description.pages218-22en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/19620610en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
crisitem.author.deptNeurology-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
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