Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10827
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dc.contributor.authorHaase-Fielitz, Anjaen
dc.contributor.authorBellomo, Rinaldoen
dc.contributor.authorDevarajan, Prasaden
dc.contributor.authorBennett, Michael Ren
dc.contributor.authorStory, David Aen
dc.contributor.authorMatalanis, Georgeen
dc.contributor.authorFrei, Ulrichen
dc.contributor.authorDragun, Duskaen
dc.contributor.authorHaase, Michaelen
dc.date.accessioned2015-05-16T00:24:05Z
dc.date.available2015-05-16T00:24:05Z
dc.date.issued2009-05-27en
dc.identifier.citationNephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association 2009; 24(11): 3349-54en
dc.identifier.govdoc19474273en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10827en
dc.description.abstractIn adult cardiac surgery, the predictive value for AKI of neutrophil gelatinase-associated lipocalin (NGAL) appears to have wide variability. The choice of definition of acute kidney injury (AKI) might, at least in part, account for such variability.In a prospective study of 100 adult cardiac surgery patients, we assessed the value of postoperative plasma NGAL in predicting AKI according to the degree of severity used for its definition.The predictive value of plasma NGAL varied according to the AKI definition used and was higher for more severe AKI (increase in creatinine >50%: mean AUC-ROC 0.79 +/- 0.01) compared to less severe AKI (>25%: mean AUC-ROC 0.65 +/- 0.02); P = 0.001. The discriminatory ability of NGAL for AKI also increased with increasing RIFLE classes (AUC-ROC R: 0.72, I: 0.79, F: 0.80) or AKIN stages (AUC-ROC 1: 0.75, 2: 0.78, 3: 0.81); P = 0.015. It was highest for the prediction of renal replacement therapy (AUC-ROC: 0.83).In adult cardiac surgery patients, the predictive value of NGAL increases with grade of AKI. This observation needs to be taken into account when interpreting any future studies of this biomarker.en
dc.language.isoenen
dc.subject.otherAcute Kidney Injury.blood.classificationen
dc.subject.otherAcute-Phase Proteinsen
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherArea Under Curveen
dc.subject.otherCardiac Surgical Proceduresen
dc.subject.otherCreatinine.blooden
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherLipocalins.blooden
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherPredictive Value of Testsen
dc.subject.otherProspective Studiesen
dc.subject.otherProto-Oncogene Proteins.blooden
dc.subject.otherROC Curveen
dc.titleThe predictive performance of plasma neutrophil gelatinase-associated lipocalin (NGAL) increases with grade of acute kidney injury.en
dc.typeJournal Articleen
dc.identifier.journaltitleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Associationen
dc.identifier.affiliationDepartment of Intensive Care, Austin Health, Melbourne, Australiaen
dc.identifier.doi10.1093/ndt/gfp234en
dc.description.pages3349-54en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/19474273en
dc.type.austinJournal Articleen
local.name.researcherBellomo, Rinaldo
item.languageiso639-1en-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
crisitem.author.deptAnaesthesia-
crisitem.author.deptCardiac Surgery-
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