Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10774
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dc.contributor.authorLubel, J S-
dc.contributor.authorHerath, C B-
dc.contributor.authorVelkoska, Elena-
dc.contributor.authorCasley, David J-
dc.contributor.authorBurrell, Louise M-
dc.contributor.authorAngus, Peter W-
dc.date.accessioned2015-05-16T00:19:40Z
dc.date.available2015-05-16T00:19:40Z
dc.date.issued2009-02-18-
dc.identifier.citationCytotechnology 2009; 58(3): 119-26en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10774en
dc.description.abstractCell culture experiments often employ the use of culture media that contain fetal calf serum (FCS). The angiotensin peptides angiotensin II and angiotensin 1-7 have opposing effects with angiotensin converting enzyme 2 (ACE2) being the enzyme predominantly responsible for generating angiotensin 1-7 from angiotensin II. The effect of FCS on angiotensin peptides has not previously been described. We have shown that FCS has ACE2 enzyme activity capable of degrading angiotensin II and generating angiotensin 1-7. Researchers should be aware that FCS possesses ACE2 activity and that heat-treating FCS to 56 degrees C only partially inhibits this enzyme activity, whereas heat-treating to 70 degrees C completely abolishes ACE2 activity.en_US
dc.language.isoenen
dc.titleAngiotensin converting enzyme 2 (ACE2) activity in fetal calf serum: implications for cell culture research.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleCytotechnologyen_US
dc.identifier.affiliationGeneral Medicineen_US
dc.identifier.doi10.1007/s10616-009-9185-0en_US
dc.description.pages119-26en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/19224387en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherAngus, Peter W
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptCardiology-
crisitem.author.deptGeneral Medicine-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
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