Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10735
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dc.contributor.authorKovac, Suzanaen
dc.contributor.authorShulkes, Arthuren
dc.contributor.authorBaldwin, Graham Sen
dc.date.accessioned2015-05-16T00:16:48Z
dc.date.available2015-05-16T00:16:48Z
dc.date.issued2009-02-01en
dc.identifier.citationCurrent Opinion in Endocrinology, Diabetes, and Obesity; 16(1): 79-85en
dc.identifier.govdoc19104240en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10735en
dc.description.abstractTo describe recent advances in the processing of gastrointestinal hormones, and the consequences for human disease of mutations in the enzymes involved.Although gastrointestinal prohormones were long regarded as devoid of biological activity, recent data indicate that the prohormones for both gastrin and gastrin-releasing peptide are bioactive, through different receptors from the mature hormones. Mutations in the family of prohormone convertases responsible for the initial steps in the processing of gastrointestinal hormones are associated with several different pathophysiological conditions in humans.Human mutational studies, when taken together with the phenotypes observed in mice deficient in the prohormone convertases, emphasize the crucial importance of the processing enzymes in mammalian biology. Although the phenotypes may often be ascribed to defective production of a mature hormone or growth factor, the recognition that the precursors are independently bioactive suggests that the increased precursor concentrations may also contribute to the symptoms. The observation that the precursors often act through different receptors from the mature hormones may permit the development of precursor-selective antagonists for therapeutic use.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherFurin.genetics.physiologyen
dc.subject.otherGastrin-Releasing Peptide.physiologyen
dc.subject.otherGastrins.physiologyen
dc.subject.otherGastrointestinal Diseases.enzymology.genetics.physiopathologyen
dc.subject.otherGastrointestinal Hormones.physiologyen
dc.subject.otherHormones.physiologyen
dc.subject.otherHumansen
dc.subject.otherMiceen
dc.subject.otherMice, Knockouten
dc.subject.otherModels, Animalen
dc.subject.otherMutationen
dc.subject.otherPeptides.genetics.metabolism.physiologyen
dc.subject.otherProprotein Convertases.physiologyen
dc.subject.otherProtein Precursors.physiologyen
dc.titlePeptide processing and biology in human disease.en
dc.typeJournal Articleen
dc.identifier.journaltitleCurrent opinion in endocrinology, diabetes, and obesityen
dc.identifier.affiliationUniversity of Melbourne, Department of Surgery, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1097/MED.0b013e3283202555en
dc.description.pages79-85en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/19104240en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
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