Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10716
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dc.contributor.authorWang, Qingjuen
dc.contributor.authorSeeman, Egoen
dc.date.accessioned2015-05-16T00:15:22Z
dc.date.available2015-05-16T00:15:22Z
dc.date.issued2008-10-01en
dc.identifier.citationBest Practice & Research. Clinical Endocrinology & Metabolism; 22(5): 687-700en
dc.identifier.govdoc19028352en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10716en
dc.description.abstractBone size, shape and internal architecture, and not just bone mass, account for differences in bone strength between individuals, sexes and races. The differences in bone morphology in old age - whether an individual's bone size and mass occupy the 5th, 50th or 95th percentile - is determined early in life. Bone traits track from the position established early in life. Genetic and environmental factors establish the morphological features of bone through the cellular machinery of bone modelling and remodelling which adapts bone to its loading circumstance by modifying its size and shape and the distribution of its mass. The need for both strength for loading and lightness for mobility are achieved by deposition of bone where it is needed and removal of bone from where it is not. The machinery has enormous capacity during growth, as can be seen in the bone structure of the elite athlete, but not during advancing age because of changes in the cellular machinery itself and in systemic hormonal regulatory factors.en
dc.language.isoenen
dc.subject.otherAge Factorsen
dc.subject.otherBone Development.physiologyen
dc.subject.otherBone Remodeling.physiologyen
dc.subject.otherBone and Bones.physiologyen
dc.subject.otherFemaleen
dc.subject.otherHuman Growth Hormone.physiologyen
dc.subject.otherHumansen
dc.subject.otherInsulin-Like Growth Factor I.physiologyen
dc.subject.otherMaleen
dc.titleSkeletal growth and peak bone strength.en
dc.typeJournal Articleen
dc.identifier.journaltitleBest practice & research. Clinical Endocrinology & metabolismen
dc.identifier.affiliationEndocrine Centre, Centaur Building, Heidelberg Repatriation Hospital/Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1016/j.beem.2008.07.008en
dc.description.pages687-700en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/19028352en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
crisitem.author.deptEndocrinology-
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