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dc.contributor.authorScott, Andrew Men
dc.contributor.authorGunawardana, Dishan Hen
dc.contributor.authorKelley, Benen
dc.contributor.authorStuckey, John Gen
dc.contributor.authorByrne, Amanda Jen
dc.contributor.authorRamshaw, Jayne Een
dc.contributor.authorFulham, Michael Jen
dc.identifier.citationJournal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine 2008; 49(9): 1451-7en
dc.description.abstractThe aims of our study were to examine the impact of PET in changing management in patients with proven or suspected colorectal cancer recurrence and to assess the impact of management change on disease-free survival.Symptomatic patients with a residual structural lesion suggestive of recurrent tumor (group A) or patients with pulmonary or hepatic metastases considered to be potentially resectable (group B) underwent PET scans. Pre-PET management plans were documented by referring clinicians unaware of the PET results, and follow-up to 12 mo was performed to determine actual management and clinical outcomes.A total of 191 patients (118 men and 73 women; mean age, 66 y) were studied. PET detected additional sites of disease in 48.4% of patients in group A and in 43.9% of patients in group B. A change in planned management was documented in 65.6% of group A and in 49.0% of group B patients. These management plans were implemented in 96% of patients. Follow-up data in group A showed progressive disease in 60.5% of patients with additional lesions detected by PET, compared with conventional imaging, and in 36.2% of patients with no additional lesions detected by PET (P=0.04). In group B, progressive disease was identified in 65.9% of patients with additional lesions detected by PET and in 39.2% of patients with no additional lesions detected by PET (P=0.01). PET also provided valuable prognostic information on patients stratified into curative- or palliative-intent groups.These data demonstrate the significant impact of PET on management and outcomes in patients with suspected recurrent colorectal cancer.en
dc.subject.otherColorectal Neoplasms.epidemiology.radionuclide imaging.therapyen
dc.subject.otherNeoplasm Recurrence, Local.epidemiology.prevention & control.radionuclide imagingen
dc.subject.otherOutcome Assessment (Health Care).methodsen
dc.subject.otherPhysician's Practice Patterns.statistics & numerical dataen
dc.subject.otherPositron-Emission Tomography.statistics & numerical dataen
dc.subject.otherProspective Studiesen
dc.subject.otherReproducibility of Resultsen
dc.subject.otherRisk Assessment.methodsen
dc.subject.otherRisk Factorsen
dc.subject.otherSensitivity and Specificityen
dc.subject.otherTreatment Outcomeen
dc.titlePET changes management and improves prognostic stratification in patients with recurrent colorectal cancer: results of a multicenter prospective study.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Nuclear Medicineen
dc.identifier.affiliationCentre for PET, Austin Hospital, Melbourne, Australiaen
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.fulltextNo Fulltext- Imaging and Therapy- Newton-John Cancer Research Institute-
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