Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10653
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dc.contributor.authorZulli, Anthony-
dc.contributor.authorYe, Bei-
dc.contributor.authorWookey, Peter J-
dc.contributor.authorBuxton, Brian F-
dc.contributor.authorHare, David L-
dc.date.accessioned2015-05-16T00:10:37Z
dc.date.available2015-05-16T00:10:37Z
dc.date.issued2008-06-19en
dc.identifier.citationThe Journal of Thoracic and Cardiovascular Surgery 2008; 136(2): 370-5en
dc.identifier.govdoc18692643en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10653en
dc.description.abstractThe radial artery is increasingly used for coronary artery bypass grafts, but its potential for spasm increases postoperative risk. Alpha-calcitonin gene-related peptide is a potent antihypertensive peptide. Thus, we set out to determine whether calcitonin gene-related peptide can impair angiotensin II-mediated vasoconstriction in human radial arteries and, if so, to determine its mechanism of action.Radial arteries were placed in organ bath chambers and preincubated with 10(-9) to 10(-7) mol/L alpha-calcitonin gene-related peptide for 20 minutes before initiating an angiotensin II dose response curve (10(-10)-10(-6) mol/L).Calcitonin gene-related peptide, 10(-7), 10(-8), 3 x 10(-9), and 10(-9) mol/L, reduced angiotensin II-mediated vasoconstriction to 30.5% +/- 7.2% (P < .001), 32.2% +/- 11.7% (P < .001), 62.6% +/- 8.4% (P < .001), and 77.6% +/- 6.7% (P < .01), respectively, compared with control (normalized to 100%). Calcitonin gene-related peptide also significantly decreased basal vascular tension in human radial arteries (P < .05 in all cases). N-nitro-L-arginine methyl ester, 4-aminopyridine, charybdotoxin, and apamin had no effect on calcitonin gene-related peptide relaxation, but Ba(2+) impaired the effects of alpha-calcitonin gene-related peptide.Alpha-calcitonin gene-related peptide dose dependently impaired angiotensin II-mediated vasoconstriction in human radial arteries, independent of nitric oxide and all potassium channels except the barium-sensitive Kir channel. Thus, calcitonin gene-related peptide is an endogenous inhibitor of angiotensin II-mediated vasoconstriction in the human radial artery.en
dc.language.isoenen
dc.subject.other4-Aminopyridine.pharmacologyen
dc.subject.otherAgeden
dc.subject.otherAngiotensin II.pharmacologyen
dc.subject.otherApamin.pharmacologyen
dc.subject.otherBarium.pharmacologyen
dc.subject.otherCalcitonin Gene-Related Peptide.pharmacologyen
dc.subject.otherCharybdotoxin.pharmacologyen
dc.subject.otherDose-Response Relationship, Drugen
dc.subject.otherEnzyme Inhibitors.pharmacologyen
dc.subject.otherHumansen
dc.subject.otherIn Vitro Techniquesen
dc.subject.otherMiddle Ageden
dc.subject.otherNG-Nitroarginine Methyl Ester.pharmacologyen
dc.subject.otherNitric Oxide.antagonists & inhibitors.metabolismen
dc.subject.otherPotassium Channel Blockers.pharmacologyen
dc.subject.otherPotassium Channels.metabolismen
dc.subject.otherRadial Arteryen
dc.subject.otherVasoconstriction.drug effectsen
dc.subject.otherVasoconstrictor Agents.pharmacologyen
dc.subject.otherVasodilator Agents.pharmacologyen
dc.titleCalcitonin gene-related peptide inhibits angiotensin II-mediated vasoconstriction in human radial arteries: role of the Kir channel.en
dc.typeJournal Articleen
dc.identifier.journaltitleThe Journal of thoracic and cardiovascular surgeryen
dc.identifier.affiliationDepartment of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1016/j.jtcvs.2007.12.064en
dc.description.pages370-5en
dc.identifier.orcid0000-0001-9554-6556-
dc.identifier.pubmedid18692643-
dc.type.austinJournal Articleen
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptCardiac Surgery-
crisitem.author.deptCardiology-
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