Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10631
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dc.contributor.authorPhillips, P Aen
dc.contributor.authorBretherton, Men
dc.contributor.authorJohnston, Colin Ien
dc.contributor.authorGray, Len
dc.date.accessioned2015-05-16T00:08:57Z
dc.date.available2015-05-16T00:08:57Z
dc.date.issued1991-07-01en
dc.identifier.citationThe American Journal of Physiology; 261(1 Pt 2): R166-71en
dc.identifier.govdoc1858944en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10631en
dc.description.abstractIn response to water deprivation or heat stress, healthy elderly men experience reduced thirst compared with a young control group. Because water deprivation and heat stress produce hypertonicity as well as reduced extracellular fluid volume, the aim of this study was to determine whether the elderly also experience reduced thirst in response to hypertonicity without extracellular fluid volume depletion. To achieve this, after an overnight fast, healthy community-dwelling nonsmoking old (65-78 yr, n = 7) and young (20-32 yr, n = 7) men received 120-min hypertonic (0.855 M) and isotonic (0.154 M) saline infusions (0.06 ml.min-1.kg-1) in double-blind randomized order at least 2 wk apart. Both groups had increased thirst (P less than 0.001) and water intake (P less than 0.05) after the hypertonic saline infusion compared with the isotonic saline infusion. However, despite similar plasma sodium increases and less plasma volume expansion during the hypertonic saline infusion compared with the young group, the old group was less thirsty (P less than 0.01) and drank less room-temperature tap water (young 11.1 +/- 1.2 ml/kg, old 3.9 +/- 0.6 ml/kg, P less than 0.001). This reduced thirst in the old group seemed to be mainly due to a lower thirst sensitivity (P less than 0.05) to hypertonicity, although there was also a tendency toward an increased thirst threshold. Plasma arginine vasopressin increases were similar for the old and young groups with hypertonic saline, without significant changes during the isotonic saline infusion in either group.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherAging.blood.physiologyen
dc.subject.otherArginine Vasopressin.blooden
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherOsmolar Concentrationen
dc.subject.otherOsmosisen
dc.subject.otherSodium.blooden
dc.subject.otherThirst.physiologyen
dc.titleReduced osmotic thirst in healthy elderly men.en
dc.typeJournal Articleen
dc.identifier.journaltitleAmerican Journal of Physiologyen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pagesR166-71en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/1858944en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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