Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10603
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dc.contributor.authorRoberts, Matthew A-
dc.contributor.authorSrivastava, Piyush M-
dc.contributor.authorMacmillan, Neil-
dc.contributor.authorHare, David L-
dc.contributor.authorRatnaike, Sujiva-
dc.contributor.authorSikaris, Ken-
dc.contributor.authorIerino, Francesco L-
dc.date.accessioned2015-05-16T00:06:50Z
dc.date.available2015-05-16T00:06:50Z
dc.date.issued2008-05-01en
dc.identifier.citationClinical Journal of the American Society of Nephrology : Cjasn 2008; 3(4): 1057-65en
dc.identifier.govdoc18450924en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10603en
dc.description.abstractLeft ventricular abnormalities contribute to cardiovascular disease in patients with chronic kidney disease and may be detected by measurement of B-type natriuretic peptide in serum.In a prospective cohort study of predialysis patients, patients who were on dialysis, and kidney transplant recipients, serum was collected and assayed for both B-type natriuretic peptide and its N-terminal fragment. Median levels were compared using nonparametric tests, and predictors of B-type natriuretic peptide were determined by linear regression. Survival analysis and Cox regression were performed to examine the association of levels of B-type natriuretic peptide with cardiovascular events and death.Levels of B-type natriuretic peptide were highest in patients who were on dialysis. Patients who were receiving dialysis and had known cardiovascular disease, were not on the waiting list for kidney transplantation, or had left ventricular systolic dysfunction on echocardiography had significantly higher levels of B-type natriuretic peptide than patients without these characteristics. Glomerular filtration rate was an important predictor of B-type natriuretic peptide levels for patients who were not on dialysis (predialysis and renal transplant recipients). Left ventricular systolic dysfunction predicted B-type natriuretic peptide levels in patients who were on dialysis. Both forms of B-type natriuretic peptide were associated with a two- to three-fold increased risk for death in patients who were on dialysis.Levels of B-type natriuretic peptide are greatest in patients who are on dialysis and have cardiovascular comorbidities and are strong predictors of death.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherBiological Markers.blooden
dc.subject.otherDialysisen
dc.subject.otherFemaleen
dc.subject.otherGlomerular Filtration Rateen
dc.subject.otherHumansen
dc.subject.otherKaplan-Meier Estimateen
dc.subject.otherKidney Failure, Chronic.blood.complications.mortality.physiopathology.therapyen
dc.subject.otherKidney Transplantationen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherNatriuretic Peptide, Brain.blooden
dc.subject.otherPeptide Fragments.blooden
dc.subject.otherPredictive Value of Testsen
dc.subject.otherProportional Hazards Modelsen
dc.subject.otherProspective Studiesen
dc.subject.otherTreatment Outcomeen
dc.subject.otherVentricular Dysfunction, Left.blood.complications.physiopathologyen
dc.titleB-type natriuretic peptides strongly predict mortality in patients who are treated with long-term dialysis.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical journal of the American Society of Nephrology : CJASNen
dc.identifier.affiliationDepartment of Nephrology, Austin Health, P.O. Box 5555, Heidelberg 3084, Australiaen
dc.identifier.doi10.2215/CJN.05151107en
dc.description.pages1057-65en
dc.identifier.orcid0000-0001-9554-6556-
dc.identifier.pubmedid18450924-
dc.type.austinJournal Articleen
local.name.researcherHare, David L
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptCardiology-
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