Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10581
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dc.contributor.authorMcManus, Julie Fen
dc.contributor.authorDavey, Rachel Aen
dc.contributor.authorMaclean, Helen Een
dc.contributor.authorDoust, Elizabeth Aen
dc.contributor.authorChiu, W S Mariaen
dc.contributor.authorSims, Natalie Aen
dc.contributor.authorBouxsein, Mary Len
dc.contributor.authorGlatt, Vaidaen
dc.contributor.authorZajac, Jeffrey Den
dc.contributor.authorDanks, Janine Aen
dc.date.accessioned2015-05-16T00:05:10Z
dc.date.available2015-05-16T00:05:10Z
dc.date.issued2008-02-13en
dc.identifier.citationBone 2008; 42(6): 1164-74en
dc.identifier.govdoc18387351en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10581en
dc.description.abstractHuman parathyroid hormone (hPTH) is currently the only treatment for osteoporosis that forms new bone. Previously we described a fish equivalent, Fugu parathyroid hormone 1 (fPth1) which has hPTH-like biological activity in vitro despite fPth1(1-34) sharing only 53% identity with hPTH(1-34). Here we demonstrate the in vivo actions of fPth1(1-34) on bone. In study 1, young male rats were injected intermittently for 30 days with fPth1 [30 microg-1,000 microg/kg body weight (b.w.), (30fPth1-1,000fPth1)] or hPTH [30 microg-100 microg/kg b.w. (30hPTH-100hPTH)]. In proximal tibiae at low doses, the fPth1 was positively correlated with trabecular bone volume/total volume (TbBV/TV) while hPTH increased TbBV/TV, trabecular thickness (TbTh) and trabecular number (TbN). 500fPth1 and 1000fPth1 increased TbBV/TV, TbTh, TbN, mineral apposition rate (MAR) and bone formation rate/bone surface (BFR/BS) with a concomitant decrease in osteoclast surface and number. In study 2 ovariectomized (OVX), osteopenic rats and sham operated (SHAM) rats were injected intermittently with 500 microg/kg b.w. of fPth1 (500fPth1) for 11 weeks. 500fPth1 treatment resulted in increased TbBV/TV (151%) and TbTh (96%) in the proximal tibiae due to increased bone formation as assessed by BFR/BS (490%) and MAR (131%). The effect was restoration of TbBV/TV to SHAM levels without any effect on bone resorption. 500fPth1 also increased TbBV/TV and TbTh in the vertebrae (L6) and cortical thickness in the mid-femora increasing bone strength at these sites. fPth1 was similarly effective in SHAM rats. Notwithstanding the low amino acid sequence homology with hPTH (1-34), we have clearly established the efficacy of fPth1 (1-34) as an anabolic bone agent.en
dc.language.isoenen
dc.subject.otherAnabolic Agents.pharmacology.therapeutic useen
dc.subject.otherAnimalsen
dc.subject.otherBiological Markers.metabolismen
dc.subject.otherBone Diseases, Metabolic.drug therapy.metabolismen
dc.subject.otherBone and Bones.anatomy & histology.drug effects.physiologyen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherOsteogenesis.drug effectsen
dc.subject.otherOsteoporosis.drug therapyen
dc.subject.otherOvariectomyen
dc.subject.otherParathyroid Hormone.pharmacology.therapeutic useen
dc.subject.otherPeptide Fragments.pharmacology.therapeutic useen
dc.subject.otherRandom Allocationen
dc.subject.otherRatsen
dc.subject.otherRats, Sprague-Dawleyen
dc.subject.otherStress, Mechanicalen
dc.subject.otherTakifuguen
dc.titleIntermittent Fugu parathyroid hormone 1 (1-34) is an anabolic bone agent in young male rats and osteopenic ovariectomized rats.en
dc.typeJournal Articleen
dc.identifier.journaltitleBoneen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin Health, Studley Road, Heidelberg, VIC, Australiaen
dc.identifier.doi10.1016/j.bone.2008.01.015en
dc.description.pages1164-74en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/18387351en
dc.type.austinJournal Articleen
local.name.researcherZajac, Jeffrey D
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptEndocrinology-
crisitem.author.deptMedicine (University of Melbourne)-
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