Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10566
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dc.contributor.authorSoulis-Liparota, Ten
dc.contributor.authorCooper, Mark Een
dc.contributor.authorPapazoglou, Den
dc.contributor.authorClarke, Ben
dc.contributor.authorJerums, Georgeen
dc.date.accessioned2015-05-16T00:04:02Z
dc.date.available2015-05-16T00:04:02Z
dc.date.issued1991-10-01en
dc.identifier.citationDiabetes; 40(10): 1328-34en
dc.identifier.govdoc1834497en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10566en
dc.description.abstractThis study evaluated the relationship between the development of fluorescence related to advanced glycosylation end products (AGEs) in the kidney and experimental diabetic nephropathy over a 32-wk period. Control, untreated diabetic, and aminoguanidine-treated diabetic rats were followed for 32 wk with eight weekly measurements of urinary albumin excretion. After 32 wk, collagen-related fluorescence in aorta and kidney (whole kidney, isolated glomeruli, and renal tubules) and glomerular ultrastructure were evaluated. Diabetes was associated with a significant increase in collagen-related fluorescence in the aorta and kidney. Aminoguanidine prevented the increases in collagen-related fluorescence in aorta, isolated glomeruli, and renal tubules but not in whole kidney. Diabetes was associated with increased albuminuria, fractional mesangial volume, and glomerular basement membrane (GBM) thickness. Aminoguanidine attenuated the rise in albuminuria and prevented mesangial expansion without influencing GBM thickness in diabetic rats. The concomitant changes in collagen-related fluorescence, albuminuria, and mesangial expansion with aminoguanidine therapy are consistent with the hypothesis that AGEs may play a role in the development of diabetic nephropathy.en
dc.language.isoenen
dc.subject.otherAlbuminuria.etiology.prevention & controlen
dc.subject.otherAnimalsen
dc.subject.otherDiabetes Mellitus, Experimental.complications.drug therapy.pathologyen
dc.subject.otherDiabetic Nephropathies.pathology.prevention & controlen
dc.subject.otherFluorescenceen
dc.subject.otherGlomerular Mesangium.drug effects.ultrastructureen
dc.subject.otherGuanidines.pharmacology.therapeutic useen
dc.subject.otherMaleen
dc.subject.otherPilot Projectsen
dc.subject.otherRandom Allocationen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred Strainsen
dc.subject.otherStreptozocinen
dc.titleRetardation by aminoguanidine of development of albuminuria, mesangial expansion, and tissue fluorescence in streptozocin-induced diabetic rat.en
dc.typeJournal Articleen
dc.identifier.journaltitleDiabetesen
dc.identifier.affiliationDepartment of Medicine, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages1328-34en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/1834497en
dc.type.austinJournal Articleen
local.name.researcherJerums, George
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptEndocrinology-
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