Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10505
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dc.contributor.authorHaase, Michaelen
dc.contributor.authorHaase-Fielitz, Anjaen
dc.contributor.authorRatnaike, Sujivaen
dc.contributor.authorReade, Michael Cen
dc.contributor.authorBagshaw, Sean Men
dc.contributor.authorMorgera, Stanislaoen
dc.contributor.authorDragun, Duskaen
dc.contributor.authorBellomo, Rinaldoen
dc.date.accessioned2015-05-15T23:58:16Z
dc.date.available2015-05-15T23:58:16Z
dc.date.issued2008-01-17en
dc.identifier.citationNephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association 2008; 23(5): 1581-7en
dc.identifier.govdoc18202091en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10505en
dc.description.abstractAll randomized controlled trials of N-acetylcysteine (NAC) in contrast media-induced nephropathy used creatinine as a marker of renal function. However, it has been suggested that NAC may lower plasma creatinine levels independent of any effects on glomerular filtration rate (GFR).At a tertiary hospital 110 cardiac surgical patients were randomly allocated to peri-operative infusion of NAC (300 mg/kg over 24 h, N = 30) or placebo (N = 80). We compared the plasma concentrations of creatinine, cystatin C and urea, the plasma creatinine/plasma cystatin C ratio and the estimated GFR at baseline and at 24 and 72 h after commencement of the infusion. We measured urinary creatinine concentration at 24 h.At baseline, the plasma creatinine/plasma cystatin C ratio did not differ between the NAC and placebo group (0.90 versus 0.92; P = 0.94). There was no significant difference in the plasma creatinine/plasma cystatin C ratio for the NAC and placebo group either during or after NAC infusion at 24 h (1.03 versus 1.00; P = 0.78) and 72 h (0.94 versus 0.89; P = 0.09). Those allocated to NAC showed no difference in urinary creatinine excretion when compared to placebo (P = 0.24).The results of our study do not demonstrate that NAC artifactually lowers creatinine measured using the Jaffé method. (ClinicalTrials.gov, NCT00332631, NCT00334191).en
dc.language.isoenen
dc.subject.otherAcetylcysteine.administration & dosage.pharmacologyen
dc.subject.otherAgeden
dc.subject.otherCardiac Surgical Proceduresen
dc.subject.otherContrast Media.adverse effectsen
dc.subject.otherCreatinine.blooden
dc.subject.otherCystatin Cen
dc.subject.otherCystatins.blooden
dc.subject.otherDouble-Blind Methoden
dc.subject.otherFemaleen
dc.subject.otherGlomerular Filtration Rate.drug effectsen
dc.subject.otherHumansen
dc.subject.otherInfusions, Intravenousen
dc.subject.otherIntraoperative Careen
dc.subject.otherKidney Diseases.etiology.physiopathology.prevention & controlen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherUrea.blooden
dc.titleN-Acetylcysteine does not artifactually lower plasma creatinine concentration.en
dc.typeJournal Articleen
dc.identifier.journaltitleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Associationen
dc.identifier.affiliationDirector of Intensive Care Research, Austin Hospital, University of Melbourne, 3084 Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1093/ndt/gfm818en
dc.description.pages1581-7en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/18202091en
dc.type.austinJournal Articleen
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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