Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10503
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dc.contributor.authorCuthbertson, Christine Men
dc.contributor.authorSu, Kim Hen
dc.contributor.authorMuralidharan, Vijayagavanen
dc.contributor.authorMillar, Ianen
dc.contributor.authorMalcontenti-Wilson, Caterinaen
dc.contributor.authorChristophi, Christopheren
dc.date.accessioned2015-05-15T23:58:07Z
dc.date.available2015-05-15T23:58:07Z
dc.date.issued2008-01-01en
dc.identifier.citationPancreas; 36(1): 70-5en
dc.identifier.govdoc18192884en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10503en
dc.description.abstractThis article aims to determine the effect of acute pancreatitis on microvascular morphology and the impact of treatment with hyperbaric oxygen (HBO).Sixty-seven male Wistar rats were induced with acute pancreatitis by retrograde bile duct injection. Rats were randomized to 12-hourly HBO or control treatment. Two rats in each group were killed at baseline and 24, 48, and 72 hours postinduction, and a cast of the pancreatic microvasculature was examined using scanning electron microscopy.Normal pancreatic vasculature is a dense network with a consistent capillary diameter. In acute pancreatitis, mean capillary diameter is increased at 24 hours (P < 0.001) and further increased at 48 hours (P = 0.007). From 24 hours, diameter heterogeneity is increased (P < 0.001) and capillary density is reduced (P < 0.001). Hyperbaric oxygen has a significant effect on vascular morphology changes from 48 hours after induction. Capillary diameter and heterogeneity of diameter are decreased by HBO (both P < 0.001). Capillary density is increased by HBO at 48 and 72 hours (P < 0.001).In acute pancreatitis, structural capillary diameter and heterogeneity of diameter increase and capillary density decreases. These parameters are all improved by HBO treatment. Hyperbaric oxygen treatment normalizes the pancreatic microvasculature after acute pancreatitis and may be a potentially effective treatment of this disease.en
dc.language.isoenen
dc.subject.otherAcute Diseaseen
dc.subject.otherAmylases.blooden
dc.subject.otherAnimalsen
dc.subject.otherCapillaries.pathologyen
dc.subject.otherHyperbaric Oxygenationen
dc.subject.otherMaleen
dc.subject.otherMicroscopy, Electron, Scanningen
dc.subject.otherPancreas.blood supplyen
dc.subject.otherPancreatitis.physiopathology.therapyen
dc.subject.otherRatsen
dc.subject.otherRats, Wistaren
dc.titleHyperbaric oxygen improves capillary morphology in severe acute pancreatitis.en
dc.typeJournal Articleen
dc.identifier.journaltitlePancreasen
dc.identifier.affiliationDepartment of Surgery, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1097/mpa.0b013e3181485863en
dc.description.pages70-5en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/18192884en
dc.type.austinJournal Articleen
local.name.researcherChristophi, Christopher
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptSurgery-
crisitem.author.deptHepatopancreatobiliary Surgery-
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