Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10480
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dc.contributor.authorFifis, Theodoraen
dc.contributor.authorLam, Ireneen
dc.contributor.authorLin, Dorisen
dc.contributor.authorMalcontenti-Wilson, Caterinaen
dc.contributor.authorChristophi, Christopheren
dc.contributor.authorLoveland, Bruceen
dc.date.accessioned2015-05-15T23:56:23Z
dc.date.available2015-05-15T23:56:23Z
dc.date.issued2007-11-21en
dc.identifier.citationVaccine 2007; 26(2): 241-9en
dc.identifier.govdoc18069095en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10480en
dc.description.abstractIn vitro adaptation of a murine colorectal cell line (MoCR) rendered it less aggressive and more immunogenic than the in vivo passaged parent tumor. Vaccination of syngeneic mice with the in vitro cultured tumor cells was shown to induce immune responses and protection against tumor challenge, thus overcoming the need for antigen selection and adjuvants. A syngeneic murine model of colorectal cancer (CRC) liver metastasis was used. In a prophylactic setting mice vaccinated with in vitro cultured tumor cells produced strong cellular immune responses and significant inhibition of tumor growth, compared to sham vaccinated controls. In a therapeutic setting however, vaccination exacerbated tumor growth, suggesting that the presence of tumor subverts the course of the immune response. The mechanisms of this subversion need to be investigated and counteracted for successful immunotherapy.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherCancer Vaccines.immunology.therapeutic useen
dc.subject.otherColorectal Neoplasms.immunology.pathology.prevention & controlen
dc.subject.otherHistocompatibility Antigens Class I.immunologyen
dc.subject.otherInterferon-gamma.immunologyen
dc.subject.otherLiver Neoplasms.immunology.pathology.prevention & control.secondaryen
dc.subject.otherMaleen
dc.subject.otherMiceen
dc.subject.otherMice, Inbred CBAen
dc.subject.otherTumor Cells, Cultureden
dc.titleVaccination with in vitro grown whole tumor cells induces strong immune responses and retards tumor growth in a murine model of colorectal liver metastases.en
dc.typeJournal Articleen
dc.identifier.journaltitleVaccineen
dc.identifier.affiliationDepartment of Surgery, University of Melbourne, Austin Health, Level 8, Lance Townsend Building, Studley Road, Heidelberg, Vic 3084, Australiaen
dc.identifier.doi10.1016/j.vaccine.2007.10.068en
dc.description.pages241-9en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/18069095en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptSurgery-
crisitem.author.deptHepatopancreatobiliary Surgery-
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