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dc.contributor.authorPeyton, Philip Jen
dc.contributor.authorChong, Michaelen
dc.contributor.authorStuart-Andrews, Christopheren
dc.contributor.authorRobinson, Gavin J Ben
dc.contributor.authorPierce, Robert Jen
dc.contributor.authorThompson, Bruce Ren
dc.identifier.citationAnesthesia and Analgesia; 105(3): 680-7en
dc.description.abstractMeasurement of the partial pressure of volatile anesthetics in blood is usually done using a "headspace equilibration" method with gas chromatography. However, it is not often performed in clinical studies because of the technical, equipment, and logistic requirements. To improve the accessibility of this measurement, we tested the use of a common infrared clinical gas analyzer, the Datex-Ohmeda Capnomac, for this purpose.After characterization of the linearity of the device in measuring the volatile anesthetic concentration in the presence of nitrous oxide, carbon dioxide, and water vapor, blood was tonometered with known concentrations of sevoflurane (actual value between 0.5% and 5.0%) in oxygen and oxygen/nitrous oxide mixtures, as well as mixtures of isoflurane and desflurane in oxygen.Mean bias (standard deviation) overall for sevoflurane in oxygen relative to the tonometered reference partial pressure was -4.5 (4.8%) of the actual concentration. This was not altered significantly by measurement in 40% oxygen/60% nitrous oxide. For isoflurane and desflurane it was -3.9 (3.3%) and -4.6 (3.8%), respectively, of the actual concentration.The accuracy and precision of measurement of volatile anesthetic gas partial pressures in blood by a double headspace equilibration technique, using a clinical infrared gas analyzer, were comparable to that achieved by previous studies using gas chromatography.en
dc.subject.otherAnesthesia, Inhalation.instrumentationen
dc.subject.otherAnesthetics, Combined.blooden
dc.subject.otherAnesthetics, Inhalation.blooden
dc.subject.otherCarbon Dioxide.blooden
dc.subject.otherChromatography, Gasen
dc.subject.otherIsoflurane.analogs & derivatives.blooden
dc.subject.otherMethyl Ethers.blooden
dc.subject.otherModels, Biologicalen
dc.subject.otherNitrous Oxide.blooden
dc.subject.otherPartial Pressureen
dc.subject.otherReproducibility of Resultsen
dc.subject.otherSpectrophotometry, Infrared.instrumentationen
dc.subject.otherTime Factorsen
dc.titleMeasurement of anesthetics in blood using a conventional infrared clinical gas analyzer.en
dc.typeJournal Articleen
dc.identifier.journaltitleAnesthesia and analgesiaen
dc.identifier.affiliationDepartment of Anaesthesia, Austin Hospital, and University of Melbourne, Melbourne, Australiaen
dc.type.austinJournal Articleen, Philip J
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristype for Breathing and Sleep-
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