Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10422
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dc.contributor.authorChan, Lie Samen
dc.contributor.authorMalcontenti-Wilson, Caterinaen
dc.contributor.authorMuralidharan, Vijayaragavanen
dc.contributor.authorChristophi, Christopheren
dc.date.accessioned2015-05-15T23:52:00Z
dc.date.available2015-05-15T23:52:00Z
dc.date.issued2007-07-08en
dc.identifier.citationAnticancer Research; 27(4B): 2317-23en
dc.identifier.govdoc17695520en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10422en
dc.description.abstractOxi4503 has been shown to inhibit tumor growth and improve survival in an animal model of colorectal (CRC) liver metastases. This agent appears to selectively target the endothelial cytoskeleton with resultant vessel occlusion and tumor necrosis.This study evaluated the pattern of tumor necrosis caused by Oxi4503, with particular emphasis on patterns of cell proliferation and apoptosis in a murine model of CRC liver metastases.A single dose of Oxi4503 caused immediate tumor vasculature collapse and subsequently tumor necrosis. There was widespread central necrosis with evidence of viable tumor cells at the periphery. Alterations in the number and spatial pattern of tumor cells undergoing apoptosis and the rate of cellular proliferation were also observed following treatment. Microvessel density was reduced following treatment, however patent vessels were still observed within the necrotic core.Although Oxi4503 caused significant tumor destruction, synergistic treatment with cytotoxic and/or anti-angiogenic agents should be considered in order to achieve complete tumor eradication and long-term survival.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherApoptosis.drug effectsen
dc.subject.otherCell Cycle.drug effectsen
dc.subject.otherCell Growth Processes.drug effectsen
dc.subject.otherColorectal Neoplasms.blood supply.drug therapy.pathologyen
dc.subject.otherDiphosphates.pharmacology.toxicityen
dc.subject.otherDisease Models, Animalen
dc.subject.otherLiver Neoplasms, Experimental.blood supply.drug therapy.pathology.secondaryen
dc.subject.otherMaleen
dc.subject.otherMiceen
dc.subject.otherMice, Inbred CBAen
dc.subject.otherNecrosisen
dc.subject.otherNeovascularization, Pathologic.drug therapy.pathologyen
dc.subject.otherStilbenes.pharmacology.toxicityen
dc.titleEffect of vascular targeting agent Oxi4503 on tumor cell kinetics in a mouse model of colorectal liver metastasis.en
dc.typeJournal Articleen
dc.identifier.journaltitleAnticancer researchen
dc.identifier.affiliationUniversity of Melbourne, Department of Surgery, Austin Hospital, Heidelberg, Victoria 3084, Australiaen
dc.description.pages2317-23en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/17695520en
dc.type.austinJournal Articleen
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.author.deptSurgery (University of Melbourne)-
crisitem.author.deptHepatopancreatobiliary Surgery-
crisitem.author.deptSurgery-
crisitem.author.deptSurgery-
crisitem.author.deptHepatopancreatobiliary Surgery-
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