Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10411
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dc.contributor.authorNikfarjam, Mehrdaden
dc.contributor.authorCuthbertson, Christine Men
dc.contributor.authorMalcontenti-Wilson, Caterinaen
dc.contributor.authorMuralidharan, Vijayaragavanen
dc.contributor.authorMillar, Ianen
dc.contributor.authorChristophi, Christopheren
dc.date.accessioned2015-05-15T23:51:11Z
dc.date.available2015-05-15T23:51:11Z
dc.date.issued2007-08-01en
dc.identifier.citationJournal of Gastrointestinal Surgery : Official Journal of the Society For Surgery of the Alimentary Tract; 11(8): 1008-15en
dc.identifier.govdoc17623267en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10411en
dc.description.abstractSevere acute pancreatitis is characterized by pancreatic necrosis, resulting in local and systemic inflammation. Hyperbaric oxygen (HBO) therapy modulates inflammation, but has not been extensively studied in pancreatitis. This study investigates the effects of HBO in a rat model of severe acute pancreatitis. Sixty-four rats were induced with severe pancreatitis using 4% sodium taurocholate and randomized to HBO treatment or control. HBO was commenced 6 h after induction (100% oxygen at 2.5 atmospheres for 90 min) and continued every 12 h for a maximum of eight treatment episodes. Surviving animals were killed at 7 days. Severity of pancreatitis was graded macroscopically and microscopically. Lung edema was calculated using wet and dry lung weights. Macroscopic and microscopic severity scores (mean +/- SE) of HBO-treated animals with pancreatitis (8.3 +/- 0.7; 9.6 +/- 0.4) were lower than those of controls (10.5 +/- 0.5; 11.1 +/- 0.4) (p = 0.02 and p = 0.03, respectively). The HBO-treated group had reduced pancreatic necrosis compared to controls (40 +/- 4% vs. 54 +/- 4%; p = 0.003). There was no difference in pulmonary edema between the groups. Median survival in the HBO-treatment group was 51 h, compared to 26 h in controls. Day-7 survival was significantly improved in the HBO-treated animals compared to controls (40% vs. 27%; p = 0.04). HBO therapy reduces overall severity, decreases the extent of necrosis, and improves survival in severe acute pancreatitis.en
dc.language.isoenen
dc.subject.otherAcute Diseaseen
dc.subject.otherAnimalsen
dc.subject.otherHyperbaric Oxygenationen
dc.subject.otherMaleen
dc.subject.otherPancreatitis.mortality.therapyen
dc.subject.otherRatsen
dc.subject.otherRats, Wistaren
dc.subject.otherSeverity of Illness Indexen
dc.subject.otherSurvival Rateen
dc.titleHyperbaric oxygen therapy reduces severity and improves survival in severe acute pancreatitis.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tracten
dc.identifier.affiliationDepartment of Surgery, University of Melbourne, Austin Hospital, Lance Townsend Building Level 8, Studley Rd, Heidelberg, Melbourne, Victoria, 3084, Australiaen
dc.identifier.doi10.1007/s11605-007-0175-2en
dc.description.pages1008-15en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/17623267en
dc.type.austinJournal Articleen
local.name.researcherChristophi, Christopher
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptSurgery (University of Melbourne)-
crisitem.author.deptSurgery (University of Melbourne)-
crisitem.author.deptHepatopancreatobiliary Surgery-
crisitem.author.deptSurgery-
crisitem.author.deptSurgery-
crisitem.author.deptHepatopancreatobiliary Surgery-
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