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https://ahro.austin.org.au/austinjspui/handle/1/10344
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DC Field | Value | Language |
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dc.contributor.author | Baldwin, Graham S | en |
dc.contributor.author | Patel, Oneel | en |
dc.contributor.author | Shulkes, Arthur | en |
dc.date.accessioned | 2015-05-15T23:46:05Z | - |
dc.date.available | 2015-05-15T23:46:05Z | - |
dc.date.issued | 2007-02-27 | en |
dc.identifier.citation | Regulatory Peptides 2007; 143(1-3): 1-14 | en |
dc.identifier.govdoc | 17395282 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/10344 | en |
dc.description.abstract | The many biological activities of the hormone gastrin-releasing peptide (GRP), including stimulation of acid secretion and of tumour growth, are mediated by the gastrin-releasing peptide receptor (GRP-R). Here sequence comparisons are utilised to investigate the likely bioactive regions of the 125 amino acid GRP precursor and of GRP-R. Comparison of the sequences of the GRP precursor from 21 species revealed homology not only in the GRP region between amino acids 1 and 30, but also in C-terminal regions from amino acids 43 to 97. This observation is consistent with recent reports that peptides derived from the C-terminal region are biologically active. Comparison of the GRP-R sequence with the related receptors NMB-R and BRS-3 revealed that the family could be distinguished from other G-protein coupled receptors by the presence of the motif GVSVFTLTALS at the cytoplasmic end of transmembrane helix 3. Comparison of the sequences of the GRP-R from 21 species revealed that the most highly conserved regions occurred in transmembrane helices 2, 3, 5, 6 and 7, and in the third intracellular loop. These results will be important in guiding future structure-function studies of the GRP precursor and of GRP receptors. | en |
dc.language.iso | en | en |
dc.subject.other | Amino Acid Sequence | en |
dc.subject.other | Animals | en |
dc.subject.other | Gastrin-Releasing Peptide.genetics.metabolism | en |
dc.subject.other | Humans | en |
dc.subject.other | Molecular Sequence Data | en |
dc.subject.other | Phylogeny | en |
dc.subject.other | Protein Binding | en |
dc.subject.other | Receptors, Bombesin.genetics.metabolism | en |
dc.title | Phylogenetic analysis of the sequences of gastrin-releasing peptide and its receptors: biological implications. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Regulatory peptides | en |
dc.identifier.affiliation | University of Melbourne, Department of Surgery, Austin Health, Studley Rd., Heidelberg, Victoria 3084, Australia | en |
dc.identifier.doi | 10.1016/j.regpep.2007.02.007 | en |
dc.description.pages | 1-14 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/17395282 | en |
dc.type.austin | Journal Article | en |
item.openairetype | Journal Article | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
Appears in Collections: | Journal articles |
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