Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10340
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dc.contributor.authorHaase, Men
dc.contributor.authorSilvester, Williamen
dc.contributor.authorUchino, Shigehikoen
dc.contributor.authorGoldsmith, Donnaen
dc.contributor.authorDavenport, Piersen
dc.contributor.authorTipping, Peteren
dc.contributor.authorBoyce, Neilen
dc.contributor.authorBellomo, Rinaldoen
dc.date.accessioned2015-05-15T23:45:46Z
dc.date.available2015-05-15T23:45:46Z
dc.date.issued2007-02-01en
dc.identifier.citationThe International Journal of Artificial Organs; 30(2): 108-17en
dc.identifier.govdoc17377905en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10340en
dc.description.abstractTo compare the hemodynamic and biological effects of high-adsorption continuous veno-venous hemofiltration (CVVH) with standard CVVH in septic shock.In a randomized cross-over clinical trial twelve patients with septic shock and multiple organ failure were enrolled at a tertiary intensive care unit. Patients were allocated to either 9 hours of high-adsorption hemofiltration (CVVH with 3 hourly filter change using AN69 hemofilters - 3FCVVH) or 9 hours of standard hemofiltration (CVVH without filter change - 1F-CVVH).Changes in hemodynamic variables, dose of noradrenaline required to maintain a mean arterial pressure greater than 75 mmHg and plasma concentrations of cytokines (IL-6, IL-8, IL-10 and IL-18) were measured. A 9-hour period of 3F-CVVH was associated with greater reduction in noradrenaline dose than a similar period of 1F-CVVH (median reduction: 16 vs. 3.5 microg/min, p=0.036; median percentage reduction: 48.1% vs. 17.5%, p=0.028). Unlike 1F-CVVH, 3F-CVVH was associated with a reduction in the plasma concentration of IL-6, IL-10 and IL-18 at 9 hours and a significant decrease 30 minutes after additional filter changes (IL-6: p<0.01, p<0.01; IL-10: p=0.03, p=0.016 and IL-18: p=0.016, p<0.01, respectively). Both, 3F-CVVH and 1F-CVVH were associated with decreased plasma concentrations of IL-8 at 9 hours (p<0.01, p<0.01, respectively). In a confirmatory ex-vivo experiment IL-6 concentrations substantially decreased during 3F-CVVH (at baseline 511 pg/mL and at end: 21 pg/mL) whereas IL-6 concentrations increased in control blood (at baseline 511 pg/mL and at end: 932 pg/mL).High-adsorption CVVH appears more effective than standard CVVH in decreasing noradrenaline requirements and plasma concentrations of cytokines in septic shock patients.en
dc.language.isoenen
dc.subject.otherAcute Kidney Injury.complications.therapyen
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherAged, 80 and overen
dc.subject.otherBlood Pressureen
dc.subject.otherFemaleen
dc.subject.otherHeart Rateen
dc.subject.otherHemofiltrationen
dc.subject.otherHumansen
dc.subject.otherInterleukin-10.blooden
dc.subject.otherInterleukin-6.blooden
dc.subject.otherInterleukin-8.blooden
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherMultiple Organ Failureen
dc.subject.otherNorepinephrineen
dc.subject.otherRenal Dialysisen
dc.subject.otherShock, Septic.blood.physiopathology.therapyen
dc.titleA pilot study of high-adsorption hemofiltration in human septic shock.en
dc.typeJournal Articleen
dc.identifier.journaltitleInternational Journal of Artificial Organsen
dc.identifier.affiliationIntensive Care Unit and Intensive Care Research, Austin Hospital, University of Melbourne, Australiaen
dc.description.pages108-17en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/17377905en
dc.type.austinJournal Articleen
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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