Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10240
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBadawy, Radwa A Ben
dc.contributor.authorCuratolo, J Men
dc.contributor.authorNewton, Mark Ren
dc.contributor.authorBerkovic, Samuel Fen
dc.contributor.authorMacdonell, Richard A Len
dc.date.accessioned2015-05-15T23:37:38Z
dc.date.available2015-05-15T23:37:38Z
dc.date.issued2006-09-26en
dc.identifier.citationNeurology; 67(6): 1018-22en
dc.identifier.govdoc17000971en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10240en
dc.description.abstractTo use transcranial magnetic stimulation (TMS) to investigate the hypothesis that sleep deprivation increases cortical excitability in people with epilepsy.We performed paired pulse TMS stimulation, using a number of interstimulus intervals (ISIs) on each hemisphere of 30 patients with untreated newly diagnosed epilepsy (15 idiopathic generalized epilepsy [IGE] and 15 focal epilepsy) and on the dominant hemisphere of 13 healthy control subjects, before and after sleep deprivation.Both hemispheres in patients with IGE and the hemisphere ipsilateral to the EEG seizure focus in those with focal epilepsy showed an increase in cortical excitability following sleep deprivation at a number of ISIs. This change in excitability was most prominent in the patients with IGE. Although there were minor changes after sleep deprivation in control subjects and the contralateral hemisphere in the focal epilepsy group seen at the 250-millisecond ISI, it was less than in the other groups.Sleep deprivation increases cortical excitability in epilepsy; the pattern of change is syndrome dependent.en
dc.language.isoenen
dc.subject.otherAdolescenten
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherCerebral Cortex.physiopathologyen
dc.subject.otherElectroencephalography.methodsen
dc.subject.otherEpilepsy.physiopathologyen
dc.subject.otherFemaleen
dc.subject.otherFunctional Lateralityen
dc.subject.otherG0 Phase.physiologyen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherSleep Deprivation.physiopathologyen
dc.subject.otherTime Factorsen
dc.subject.otherTranscranial Magnetic Stimulation.methodsen
dc.titleSleep deprivation increases cortical excitability in epilepsy: syndrome-specific effects.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeurologyen
dc.identifier.affiliationDepartment of Neurology, Austin Health, Studley Road, Heidelberg, Victoria 3084, Australiaen
dc.identifier.doi10.1212/01.wnl.0000237392.64230.f7en
dc.description.pages1018-22en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/17000971en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
crisitem.author.deptNeurology-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

8
checked on Feb 1, 2023

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.