Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10185
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dc.contributor.authorMacIsaac, Richard Jen
dc.contributor.authorPanagiotopoulos, Siannaen
dc.contributor.authorMcNeil, Karen Jen
dc.contributor.authorSmith, Trudy Jen
dc.contributor.authorTsalamandris, Conen
dc.contributor.authorHao, Humingen
dc.contributor.authorMatthews, P Geoffreyen
dc.contributor.authorThomas, Merlin Cen
dc.contributor.authorPower, David Anthonyen
dc.contributor.authorJerums, Georgeen
dc.date.accessioned2015-05-15T23:33:22Z-
dc.date.available2015-05-15T23:33:22Z-
dc.date.issued2006-07-01en
dc.identifier.citationDiabetes Care; 29(7): 1560-6en
dc.identifier.govdoc16801579en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10185en
dc.description.abstractTo investigate the role of intrarenal vascular disease in the pathogenesis of nonalbuminuric renal insufficiency in type 2 diabetes.We studied 325 unselected clinic patients who had sufficient clinical and biochemical information to calculate an estimated glomerular filtration rate (eGFR) using the Modified Diet in Renal Disease six-variable formula, at least two estimations of urinary albumin excretion rates (AER), and a renal duplex scan to estimate the resistance index of the interlobar renal arteries. The resistance index, measured as part of a complications surveillance program, was compared in patients with an eGFR < or >or=60 ml/min per 1.73 m(2) who were further stratified into normo- (AER <20), micro- (20-200), or macroalbuminuria (> 200 microg/min) categories.Patients with an eGFR <60 ml/min per 1.73 m(2) had a higher resistance index of the renal interlobar arteries compared with patients with an eGFR >or=60 ml/min per 1.73 m(2). However, the resistance index was elevated to a similar extent in patients with an eGFR <60 ml/min per 1.73 m(2) regardless of albuminuric status (normo- 0.74 +/- 0.01, micro- 0.73 +/- 0.01, and macroalbuminuria resistance index 0.75 +/- 0.11). Multiple regression analysis revealed that increased age (P < 0.0001), elevated BMI (P = 0.0001), decreased eGFR (P < 0.01), and decreased diastolic blood pressure (P < 0.01), but not an increased AER, were independently associated with an elevated resistance index in patients with impaired renal function.Subjects with type 2 diabetes and reduced glomerular filtration rate had similar degrees of intrarenal vascular disease, as measured by the intrarenal arterial resistance index, regardless of their AER status. The pathological mechanisms that determine the relationship between impaired renal function and AER status in subjects with type 2 diabetes remain to be elucidated.en
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherAlbuminuria.etiologyen
dc.subject.otherDiabetes Mellitus, Type 2.complicationsen
dc.subject.otherDiabetic Nephropathies.etiology.ultrasonography.urineen
dc.subject.otherFemaleen
dc.subject.otherGlomerular Filtration Rateen
dc.subject.otherHumansen
dc.subject.otherKidney Failure, Chronic.etiologyen
dc.subject.otherMaleen
dc.subject.otherRenal Artery.physiology.ultrasonographyen
dc.subject.otherVascular Diseases.etiologyen
dc.titleIs nonalbuminuric renal insufficiency in type 2 diabetes related to an increase in intrarenal vascular disease?en
dc.typeJournal Articleen
dc.identifier.journaltitleDiabetes Careen
dc.identifier.affiliationEndocrine Centre and Department of Medicine, Austin Health, Heidelberg Repatriation Hospital, Heidelberg West, Victoria, Australiaen
dc.identifier.doi10.2337/dc05-1788en
dc.description.pages1560-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/16801579en
dc.identifier.orcid0000-0002-0845-0001-
dc.type.austinJournal Articleen
local.name.researcherHao, Huming
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptOffice for Research-
crisitem.author.deptRadiology-
crisitem.author.deptEndocrinology-
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