Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10177
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dc.contributor.authorClark, David Jen
dc.contributor.authorLessio, Saraen
dc.contributor.authorO'Donoghue, Margareten
dc.contributor.authorTsalamandris, Conen
dc.contributor.authorSchainfeld, Roberten
dc.contributor.authorRosenfield, Kennethen
dc.date.accessioned2015-05-15T23:32:43Z
dc.date.available2015-05-15T23:32:43Z
dc.date.issued2006-05-30en
dc.identifier.citationJournal of the American College of Cardiology 2006; 47(12): 2390-6en
dc.identifier.govdoc16781364en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10177en
dc.description.abstractThe aim of this study was to determine the mechanisms and predictors of carotid artery restenosis after carotid artery stenting (CAS) using serial intravascular ultrasound (IVUS) imaging.Carotid artery stenting is increasingly used to treat high-grade obstructive carotid disease, but our knowledge of carotid in-stent restenosis and remodeling remains limited.Post-procedural and 6-month (median 6 months) follow-up quantitative carotid angiography and IVUS were performed after self-expanding stent deployment in 50 internal carotid arteries (ICA). The IVUS measurements at multiple designated sites included minimal luminal diameter, lumen area, stent area (SA), and neointimal hyperplasia area (NIH).Late stent enlargement at follow-up was found at all segments, and the percentage increase was greatest at the ICA lesion site (mean +/- SD, 48.9 +/- 35.3%). The NIH, expressed as a percentage of SA, was seen within all segments of the stent and was greatest at the ICA lesion site (37.3 +/- 23.3%). There was a strong positive correlation between the amount of NIH and late stent enlargement (r = 0.64; p < 0.001). Immediate post-procedural minimum ICA SA (r = -0.37; p < 0.01) and stent expansion (r = -0.44; p = 0.001) correlated negatively with the percentage restenotic area at follow-up.Although self-expanding carotid stents generate considerable neointimal hyperplasia, the process is balanced by marked late stent enlargement. Small stent dimensions immediately post-procedure were associated with a higher risk of restenosis.en
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherAged, 80 and overen
dc.subject.otherCarotid Stenosis.surgery.ultrasonographyen
dc.subject.otherFemaleen
dc.subject.otherFollow-Up Studiesen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherPrognosisen
dc.subject.otherRecurrenceen
dc.subject.otherStentsen
dc.subject.otherUltrasonography, Interventionalen
dc.titleMechanisms and predictors of carotid artery stent restenosis: a serial intravascular ultrasound study.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of the American College of Cardiologyen
dc.identifier.affiliationDepartment of Cardiology, Austin Hospital, Melbourne, Australiaen
dc.identifier.doi10.1016/j.jacc.2006.01.076en
dc.description.pages2390-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/16781364en
dc.type.austinJournal Articleen
local.name.researcherClark, David J
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
crisitem.author.deptCardiology-
crisitem.author.deptUniversity of Melbourne Clinical School-
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