Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10171
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dc.contributor.authorBerkovic, Samuel Fen
dc.contributor.authorMulley, John Cen
dc.contributor.authorScheffer, Ingrid Een
dc.contributor.authorPetrou, Stevenen
dc.date.accessioned2015-05-15T23:32:15Z
dc.date.available2015-05-15T23:32:15Z
dc.date.issued2006-07-01en
dc.identifier.citationTrends in Neurosciences; 29(7): 391-7en
dc.identifier.govdoc16769131en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10171en
dc.description.abstractEpilepsies, once regarded as due to demoniacal possession, can have both genetic and acquired causes, with interaction of these factors in many cases. To date, nearly all the genes discovered to be involved in human epilepsies encode subunits of ion channels, both voltage-gated and ligand-gated. Established acquired causes include serious brain trauma, stroke, tumours and infective lesions. Thus, in terms of exploring the neurobiology of "nature and nurture" in disease, the epilepsies are an excellent paradigm. Here, we review the evidence and discuss the possibility that ion channels are a common biological substrate for both genetic and acquired epilepsies. This review is part of the INMED/TINS special issue "Nature and nurture in brain development and neurological disorders", based on presentations at the annual INMED/TINS symposium (http://inmednet.com/).en
dc.language.isoenen
dc.subject.otherAnoxia.complications.geneticsen
dc.subject.otherBrain Neoplasms.complications.geneticsen
dc.subject.otherEnvironmenten
dc.subject.otherEpilepsy.etiology.genetics.physiopathologyen
dc.subject.otherHumansen
dc.subject.otherIon Channels.genetics.metabolismen
dc.subject.otherStroke.complications.geneticsen
dc.titleHuman epilepsies: interaction of genetic and acquired factors.en
dc.typeJournal Articleen
dc.identifier.journaltitleTrends in neurosciencesen
dc.identifier.affiliationDepartment of Medicine and Epilepsy Research, University of Melbourne, Austin Health, Heidelberg West, Victoria 3081, Australiaen
dc.identifier.doi10.1016/j.tins.2006.05.009en
dc.description.pages391-7en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/16769131en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
crisitem.author.deptEpilepsy Research Centre-
Appears in Collections:Journal articles
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