Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10166
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dc.contributor.authorBerlowitz, David Jen
dc.contributor.authorDetering, Karen Men
dc.contributor.authorSchachter, Lindaen
dc.date.accessioned2015-05-15T23:31:52Z-
dc.date.available2015-05-15T23:31:52Z-
dc.date.issued2006-06-01en
dc.identifier.citationAmyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases; 7(2): 100-6en
dc.identifier.govdoc16753974en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10166en
dc.description.abstractPrevious studies have demonstrated that domiciliary ventilatory support improves survival, quality of life and cognitive function in motor neuron disease (MND). These benefits are partly attributed to better sleep quality and less hypoxia. In a retrospective analysis we compared the effect of non-invasive (NPPV, n = 52), tracheostomy (TPPV, n = 23) and no ventilation (n = 43) on sleep and survival in MND patients over a seven-year period. The TPPV and NPPV groups had more sleep arousals (AI, p = 0.024), more respiratory events (p = 0.001) and more time asleep with an oxygen saturation less than 90% (%TST with SpO2<90%, p = 0.01), than those who were not ventilated. After treatment with TPPV or NPPV, the percentage of rapid eye movement sleep increased (p<0.001) and the %TST with Sp02<90% (p = 0.006) and AI (p = 0.001) decreased. Improvements were larger and more consistent with NPPV. The median survival of those who used TPPV was 41 months, NPPV 32 months and of those not ventilated was 25 months, significantly different four years (p = 0.0497) after symptom onset. In this retrospective cohort of MND patients, ventilation, particularly NPPV, markedly improved sleep and conferred a modest survival advantage.en
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherArousalen
dc.subject.otherData Interpretation, Statisticalen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherMotor Neuron Disease.mortality.psychology.therapyen
dc.subject.otherPolysomnographyen
dc.subject.otherRespiration, Artificialen
dc.subject.otherRespiratory Function Testsen
dc.subject.otherRetrospective Studiesen
dc.subject.otherSleep.physiologyen
dc.subject.otherSpirometryen
dc.subject.otherSurvival Analysisen
dc.subject.otherTracheostomyen
dc.titleA retrospective analysis of sleep quality and survival with domiciliary ventilatory support in motor neuron disease.en
dc.typeJournal Articleen
dc.identifier.journaltitleAmyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseasesen
dc.identifier.affiliationInstitute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1080/14660820500504645en
dc.description.pages100-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/16753974en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptPhysiotherapy-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
crisitem.author.deptAdvance Care Planning-
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