Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10149
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dc.contributor.authorJackson, Heather Men
dc.contributor.authorDimopoulos, Nektariaen
dc.contributor.authorMifsud, Nicole Aen
dc.contributor.authorTai, Tsin Yeeen
dc.contributor.authorChen, Qiyuanen
dc.contributor.authorSvobodova, Suzanneen
dc.contributor.authorBrowning, Judyen
dc.contributor.authorLuescher, Immanuel Fen
dc.contributor.authorStockert, Lisaen
dc.contributor.authorOld, Lloyd Jen
dc.contributor.authorDavis, Ian Den
dc.contributor.authorCebon, Jonathan Sen
dc.contributor.authorChen, Weisanen
dc.date.accessioned2015-05-15T23:30:32Z
dc.date.available2015-05-15T23:30:32Z
dc.date.issued2006-05-15en
dc.identifier.citationJournal of Immunology (baltimore, Md. : 1950); 176(10): 5908-17en
dc.identifier.govdoc16670298en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10149en
dc.description.abstractImmunodominance has been well-demonstrated in many antiviral and antibacterial systems, but much less so in the setting of immune responses against cancer. Tumor Ag-specific CD8+ T cells keep cancer cells in check via immunosurveillance and shape tumor development through immunoediting. Because most tumor Ags are self Ags, the breadth and depth of antitumor immune responses have not been well-appreciated. To design and develop antitumor vaccines, it is important to understand the immunodominance hierarchy and its underlying mechanisms, and to identify the most immunodominant tumor Ag-specific T cells. We have comprehensively analyzed spontaneous cellular immune responses of one individual and show that multiple tumor Ags are targeted by the patient's immune system, especially the "cancer-testis" tumor Ag NY-ESO-1. The pattern of anti-NY-ESO-1 T cell responses in this patient closely resembles the classical broad yet hierarchical antiviral immunity and was confirmed in a second subject.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherAntigens, Neoplasm.physiologyen
dc.subject.otherCD4-Positive T-Lymphocytes.immunology.metabolismen
dc.subject.otherCD8-Positive T-Lymphocytes.immunology.metabolismen
dc.subject.otherCHO Cellsen
dc.subject.otherCell Line, Transformeden
dc.subject.otherCell Line, Tumoren
dc.subject.otherCricetinaeen
dc.subject.otherCricetulusen
dc.subject.otherEpitopes, T-Lymphocyte.immunology.metabolismen
dc.subject.otherHumansen
dc.subject.otherImmunity, Innateen
dc.subject.otherImmunodominant Epitopes.immunology.metabolismen
dc.subject.otherMaleen
dc.subject.otherMembrane Proteins.physiologyen
dc.subject.otherMiddle Ageden
dc.titleStriking immunodominance hierarchy of naturally occurring CD8+ and CD4+ T cell responses to tumor antigen NY-ESO-1.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Immunology (Baltimore, Md. : 1950)en
dc.identifier.affiliationLudwig Institute for Cancer Research, Austin Health, Studley Road, Heidelberg, Victoria 3084, Australiaen
dc.description.pages5908-17en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/16670298en
dc.type.austinJournal Articleen
local.name.researcherCebon, Jonathan S
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
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