Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10136
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dc.contributor.authorCuthbertson, C Men
dc.contributor.authorChristophi, Christopheren
dc.date.accessioned2015-05-15T23:29:29Z
dc.date.available2015-05-15T23:29:29Z
dc.date.issued2006-05-01en
dc.identifier.citationThe British Journal of Surgery; 93(5): 518-30en
dc.identifier.govdoc16607683en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10136en
dc.description.abstractSevere acute pancreatitis is characterized by pancreatic necrosis, resulting in local and systemic inflammation. Pancreatitis affects both the systemic and pancreatic vasculature. This review focuses on the underlying processes involved in the changes of microvascular anatomy following acute pancreatitis.A Medline/PubMed search (January 1966 to December 2005) with manual cross-referencing was conducted. All relevant articles investigating the pancreatic microcirculatory anatomy and the effect of pancreatitis on the microcirculation were included.The pancreas is susceptible to ischaemic insult, which can exacerbate acute pancreatitis. There is also increasing evidence of pancreatic and systemic microvascular disturbances in the pathogenesis of pancreatitis, including vasoconstriction, shunting, inadequate perfusion, and increased blood viscosity and coagulation. These processes may be caused or exacerbated by ischaemia-reperfusion injury and the development of oxygen-derived free radicals.Acute pancreatitis impairs the pancreatic and systemic microcirculation, which is a key pathological process in the development of severe necrotizing disease.en
dc.language.isoenen
dc.subject.otherAcute Diseaseen
dc.subject.otherBlood Coagulation Disorders.etiologyen
dc.subject.otherEndothelium, Vascular.physiologyen
dc.subject.otherHumansen
dc.subject.otherMicrocirculation.physiologyen
dc.subject.otherPancreas.blood supplyen
dc.subject.otherPancreatitis.complications.physiopathologyen
dc.subject.otherReperfusion Injury.etiology.physiopathologyen
dc.subject.otherVascular Diseases.etiology.physiopathologyen
dc.titleDisturbances of the microcirculation in acute pancreatitis.en
dc.typeJournal Articleen
dc.identifier.journaltitleThe British journal of surgeryen
dc.identifier.affiliationDepartment of Surgery, University of Melbourne, Austin Hospital, Lance Townsend Building Level 8, Heidelberg, Victoria 3084, Australiaen
dc.identifier.doi10.1002/bjs.5316en
dc.description.pages518-30en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/16607683en
dc.type.austinJournal Articleen
local.name.researcherChristophi, Christopher
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptSurgery-
crisitem.author.deptHepatopancreatobiliary Surgery-
Appears in Collections:Journal articles
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