Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10114
Full metadata record
DC FieldValueLanguage
dc.contributor.authorVadlamudi, Lataen
dc.contributor.authorKjeldsen, Marianne Jen
dc.contributor.authorCorey, Linda Aen
dc.contributor.authorSolaas, Marit Hen
dc.contributor.authorFriis, Mogen Len
dc.contributor.authorPellock, John Men
dc.contributor.authorNakken, Karl Oen
dc.contributor.authorMilne, Roger Len
dc.contributor.authorScheffer, Ingrid Een
dc.contributor.authorHarvey, A Simonen
dc.contributor.authorHopper, John Len
dc.contributor.authorBerkovic, Samuel Fen
dc.date.accessioned2015-05-15T23:27:48Z
dc.date.available2015-05-15T23:27:48Z
dc.date.issued2006-03-01en
dc.identifier.citationEpilepsia; 47(3): 550-5en
dc.identifier.govdoc16529620en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10114en
dc.description.abstractBenign rolandic epilepsy (BRE) is considered a genetically determined idiopathic partial epilepsy. We analyzed a large sample of twins from four international twin registers to probe the genetics of BRE. We also aim to synthesize the apparently conflicting family and twin data into a model of BRE etiology.Large population-based twin registries of epilepsies from Odense (Denmark), Richmond, Virginia (United States), and Oslo (Norway) were reviewed for BRE cases and added to our Australian twin data. Diagnosis of classic BRE was based on electroclinical criteria with normal neurologic development. Cases with a compatible electroclinical picture but abnormal neurologic development were termed non-classic BRE.Eighteen twin pairs were identified (10 monozygous; eight dizygous) of whom at least one twin was diagnosed with classic BRE among a total sample of 1,952 twin pairs validated for seizures, and all were discordant for BRE. The estimated monozygous pairwise concordance for BRE in this sample was 0.0 [95% confidence interval (CI), 0.0-0.3). Four twin pairs (one monozygous, three dizygous) had non-classic BRE, and all co-twins had seizures.The twin data showing an absence of any concordant twin pairs with classic BRE suggest that noninherited factors are of major importance in BRE. Modelling the data shows that the familial occurrence of centrotemporal spikes makes only a minor contribution to the familial aggregation of BRE. Genetic factors are probably more important in non-classic BRE. The etiology and mode(s) of inheritance of BRE are much more complicated than initially conceptualized.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAge of Onseten
dc.subject.otherAustralia.epidemiologyen
dc.subject.otherDenmark.epidemiologyen
dc.subject.otherDiseases in Twins.diagnosis.epidemiology.geneticsen
dc.subject.otherElectroencephalography.statistics & numerical dataen
dc.subject.otherEpilepsy, Rolandic.diagnosis.epidemiology.geneticsen
dc.subject.otherFamilyen
dc.subject.otherFemaleen
dc.subject.otherGenetic Heterogeneityen
dc.subject.otherGenetic Variationen
dc.subject.otherGenotypeen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherModels, Geneticen
dc.subject.otherNorway.epidemiologyen
dc.subject.otherPedigreeen
dc.subject.otherPrevalenceen
dc.subject.otherTwins, Dizygotic.geneticsen
dc.subject.otherTwins, Monozygotic.geneticsen
dc.subject.otherUnited States.epidemiologyen
dc.titleAnalyzing the etiology of benign rolandic epilepsy: a multicenter twin collaboration.en
dc.typeJournal Articleen
dc.identifier.journaltitleEpilepsiaen
dc.identifier.affiliationEpilepsy Research Centre, Department of Medicine (Neurology), University of Melbourne, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1111/j.1528-1167.2006.00466.xen
dc.description.pages550-5en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/16529620en
dc.type.austinJournal Articleen
local.name.researcherBerkovic, Samuel F
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

30
checked on Feb 23, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.