Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10101
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dc.contributor.authorLamont, Benjamin Jen
dc.contributor.authorVisinoni, Sherleyen
dc.contributor.authorFam, Barbara Cen
dc.contributor.authorKebede, Melkamen
dc.contributor.authorWeinrich, Blaiseen
dc.contributor.authorPapapostolou, Stavroulaen
dc.contributor.authorMassinet, Heleneen
dc.contributor.authorProietto, Josephen
dc.contributor.authorFavaloro, Jenny Men
dc.contributor.authorAndrikopoulos, Sofianosen
dc.date.accessioned2015-05-15T23:26:48Z
dc.date.available2015-05-15T23:26:48Z
dc.date.issued2006-02-23en
dc.identifier.citationEndocrinology 2006; 147(6): 2764-72en
dc.identifier.govdoc16497803en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10101en
dc.description.abstractIn type 2 diabetes, increased endogenous glucose production (EGP) as a result of elevated gluconeogenesis contributes to hyperglycemia. An increase in glycerol gluconeogenesis has led to the suggestion that, in obese human subjects with type 2 diabetes, there may be an increase in the activity of the gluconeogenic enzyme fructose-1,6-bisphosphatase (FBPase). The aim of this study was to generate transgenic mice that overexpress human liver FBPase in the liver and assess the consequences to whole-body and hepatic glucose metabolism. FBPase transgenic mice had significantly higher levels of transgene expression in the liver and, as a result, had increased FBPase protein and enzyme activity levels in the liver. This resulted in an increase in the rate of glycerol conversion to glucose but not in EGP. The increased expression of FBPase in the liver did not result in any significant differences compared with littermate control mice in insulin or glucose tolerance. Therefore, it appears that, on its own, an increase in FBPase does not lead to impaired regulation of EGP and hence does not affect whole-body glucose metabolism. This suggests that, for EGP to be increased, other factors associated with obesity are also required.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherBlood Glucose.analysisen
dc.subject.otherFemaleen
dc.subject.otherFructose-Bisphosphatase.genetics.physiologyen
dc.subject.otherGluconeogenesisen
dc.subject.otherGlycerol.metabolismen
dc.subject.otherHumansen
dc.subject.otherInsulin Resistanceen
dc.subject.otherLiver.enzymologyen
dc.subject.otherMaleen
dc.subject.otherMiceen
dc.subject.otherMice, Inbred C57BLen
dc.subject.otherMice, Transgenicen
dc.subject.otherPhosphoenolpyruvate Carboxykinase (GTP).genetics.physiologyen
dc.titleExpression of human fructose-1,6-bisphosphatase in the liver of transgenic mice results in increased glycerol gluconeogenesis.en
dc.typeJournal Articleen
dc.identifier.journaltitleEndocrinologyen
dc.identifier.affiliationDepartment of Medicine (Austin Health and Northern Health), University of Melbourne, Heidelberg Repatriation Hospital, Heidelberg Heights, Victoria 3081, Australiaen
dc.identifier.doi10.1210/en.2005-1498en
dc.description.pages2764-72en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/16497803en
dc.type.austinJournal Articleen
local.name.researcherProietto, Joseph
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptMedicine (University of Melbourne)-
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