Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10075
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dc.contributor.authorPell, Gaby Sen
dc.contributor.authorBriellmann, Regula Sen
dc.contributor.authorWaites, Anthony Ben
dc.contributor.authorAbbott, David Fen
dc.contributor.authorLewis, David Pen
dc.contributor.authorJackson, Graeme Den
dc.date.accessioned2015-05-15T23:24:49Z
dc.date.available2015-05-15T23:24:49Z
dc.date.issued2006-02-01en
dc.identifier.citationJournal of Magnetic Resonance Imaging : Jmri; 23(2): 248-52en
dc.identifier.govdoc16416434en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10075en
dc.description.abstractTo optimize the accuracy and precision of T2 measurements using the standard Carr-Purcell-Meiboom-Gill (CPMG) sequence. T2 values obtained with this technique are normally sensitive to imperfect refocusing due to the formation of unwanted stimulated echoes.Modifications are made to the refocusing slice selection width and the interleaving scheme. A widened refocusing slice improves the uniformity of the refocusing flip angle across the slice. A slow spin echo acquisition provided "gold standard" T2 values. Repeated T2 measurements in phantom and human studies are used to compare the accuracy and precision of the optimized and non-optimized CPMG implementations.The required slice thickness ratio between refocusing and excitation slice widths is found to be 3:1 for typical optimized radiofrequency pulses. T2 values obtained using this optimized implementation more closely correspond to "gold standard" values. Repeated T2 measurements indicate significantly improved correspondence between data and model. A reduction in the fitting error of approximately 70% is demonstrated for phantoms.We demonstrate that a relatively simple change to the CPMG relaxometry sequence parameters from the default setup yields significant improvements in the accuracy and precision of T2 measurements.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherArtifactsen
dc.subject.otherElectron Spin Resonance Spectroscopyen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMagnetic Resonance Imaging.instrumentation.methodsen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherPhantoms, Imagingen
dc.subject.otherSensitivity and Specificityen
dc.subject.otherSignal Processing, Computer-Assisteden
dc.subject.otherSoftware Validationen
dc.titleOptimized clinical T2 relaxometry with a standard CPMG sequence.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of magnetic resonance imaging : JMRIen
dc.identifier.affiliationBrain Research Institute, Austin Health, Heidelberg West, Victoria, Australiaen
dc.identifier.doi10.1002/jmri.20490en
dc.description.pages248-52en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/16416434en
dc.type.austinJournal Articleen
local.name.researcherAbbott, David F
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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