Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10025
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dc.contributor.authorDerry, Christopher Pen
dc.contributor.authorBenjamin, Christopheren
dc.contributor.authorBladin, Peter Fen
dc.contributor.authorle Bars, Didieren
dc.contributor.authorTochon-Danguy, Henrien
dc.contributor.authorBerkovic, Samuel Fen
dc.contributor.authorZimmer, Lucen
dc.contributor.authorCostes, Nicolasen
dc.contributor.authorMulligan, Rachel Sen
dc.contributor.authorReutens, David Cen
dc.date.accessioned2015-05-15T23:20:59Z
dc.date.available2015-05-15T23:20:59Z
dc.date.issued2005-11-04en
dc.identifier.citationNeuroimage 2005; 30(2): 341-8en
dc.identifier.govdoc16275016en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10025en
dc.description.abstractData from animal studies suggest that serotonin release promotes wakefulness and suppresses REM sleep, but there are dangers in extrapolating these findings to humans. Binding of the radioligand [18F]MPPF to 5HT1A receptors is sensitive to levels of endogenous serotonin. In this study, we aimed to demonstrate changes in serotonin receptor availability in the human brain in wakefulness and sleep using [18F]MPPF and positron emission tomography. 14 subjects with narcolepsy cataplexy underwent [18F]MPPF PET scans in wakefulness and in sleep. Subjects who used the stimulant methylphenidate took their normal medication for the wake scan but omitted it prior to the sleep scan. The change in binding potential (BP) between the sleep and wake scans was examined using paired t test. Methylphenidate is thought to have little or no effect on serotonergic neurotransmission, and in order to confirm the absence of an effect on [18F]MPPF binding, a concurrent study was performed using a beta-microprobe technique to examine the effect of methylphenidate administration on [18F]MPPF binding in Sprague-Dawley rats. The human study showed a significant increase in [18F]MPPF binding in sleep compared to wakefulness in the whole brain and all regions of interest examined (temporal cortex, mesial temporal region and cingulate cortex). The beta-microprobe study confirmed that methylphenidate administration had no effect on [18F]MPPF binding. These findings indicate that serotonin receptor availability is increased in sleep compared to wakefulness in narcoleptic humans.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherAnimalsen
dc.subject.otherBlood Pressure.physiologyen
dc.subject.otherBrain.radionuclide imagingen
dc.subject.otherCentral Nervous System Stimulants.pharmacologyen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherKineticsen
dc.subject.otherMagnetic Resonance Imagingen
dc.subject.otherMaleen
dc.subject.otherMethylphenidate.pharmacologyen
dc.subject.otherMiddle Ageden
dc.subject.otherNarcolepsy.metabolism.radionuclide imagingen
dc.subject.otherPiperazines.diagnostic useen
dc.subject.otherPolysomnographyen
dc.subject.otherPositron-Emission Tomographyen
dc.subject.otherPyridines.diagnostic useen
dc.subject.otherRadiopharmaceuticalsen
dc.subject.otherRatsen
dc.subject.otherRats, Sprague-Dawleyen
dc.subject.otherReceptor, Serotonin, 5-HT1A.drug effectsen
dc.subject.otherReceptors, Serotonin.physiologyen
dc.subject.otherSerotonin.metabolismen
dc.subject.otherSleep.physiologyen
dc.titleIncreased serotonin receptor availability in human sleep: evidence from an [18F]MPPF PET study in narcolepsy.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeuroImageen
dc.identifier.affiliationEpilepsy Research Centre, Austin Health, Victoria, Australiaen
dc.identifier.doi10.1016/j.neuroimage.2005.09.052en
dc.description.pages341-8en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/16275016en
dc.type.austinJournal Articleen
local.name.researcherBerkovic, Samuel F
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
crisitem.author.deptNeurology-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
crisitem.author.deptMolecular Imaging and Therapy-
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