Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9973
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dc.contributor.authorZulli, Anthony-
dc.contributor.authorHare, David L-
dc.contributor.authorBuxton, Brian F-
dc.contributor.authorBlack, M Jane-
dc.date.accessioned2015-05-15T23:16:27Z
dc.date.available2015-05-15T23:16:27Z
dc.date.issued2005-07-27en
dc.identifier.citationAtherosclerosis 2005; 185(2): 278-81en
dc.identifier.govdoc16054151en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/9973en
dc.description.abstractLimited evidence suggests that myocardial fibrosis might be associated with dietary cardiovascular risk factors.To investigate the effects of high dietary cholesterol, methionine (the precursor to homocysteine), and the combination of the two diets on myocardial fibrosis.Rabbits were randomly allocated into four dietary groups for 12 weeks: control (Con), 1% methionine (Meth), 0.5% cholesterol (Chol) or 1% methionine plus 0.5% cholesterol (MethChol).Myocardial fibrosis was not significantly increased in Chol or Meth. However, interstitial fibrosis increased by 85% (p = 0.03) and perivascular fibrosis 28-fold (p < 0.01) in the MethChol group compared to Con.These results suggest that high levels of dietary cholesterol or methionine alone do not significantly increase myocardial collagen content. However, the combination of the two diets does cause myocardial fibrosis. Therefore, excessive cholesterol and methionine intake may be an important pathogenic factor in the development of myocardial fibrosis.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherCholesterol, Dietary.adverse effectsen
dc.subject.otherCollagen.metabolismen
dc.subject.otherCoronary Vessels.metabolism.pathologyen
dc.subject.otherFibrosisen
dc.subject.otherMaleen
dc.subject.otherMethionine.administration & dosage.adverse effectsen
dc.subject.otherMyocardium.pathologyen
dc.subject.otherRabbitsen
dc.titleThe combination of high dietary methionine plus cholesterol induces myocardial fibrosis in rabbits.en
dc.typeJournal Articleen
dc.identifier.journaltitleAtherosclerosisen
dc.identifier.affiliationVascular Laboratory, Department of Cardiology, University of Melbourne, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1016/j.atherosclerosis.2005.06.036en
dc.description.pages278-81en
dc.identifier.orcid0000-0001-9554-6556-
dc.identifier.pubmedid16054151-
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptCardiology-
crisitem.author.deptCardiac Surgery-
Appears in Collections:Journal articles
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