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Title: The combination of high dietary methionine plus cholesterol induces myocardial fibrosis in rabbits.
Austin Authors: Zulli, Anthony;Hare, David L ;Buxton, Brian F ;Black, M Jane
Affiliation: Vascular Laboratory, Department of Cardiology, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 27-Jul-2005
Publication information: Atherosclerosis 2005; 185(2): 278-81
Abstract: Limited evidence suggests that myocardial fibrosis might be associated with dietary cardiovascular risk factors.To investigate the effects of high dietary cholesterol, methionine (the precursor to homocysteine), and the combination of the two diets on myocardial fibrosis.Rabbits were randomly allocated into four dietary groups for 12 weeks: control (Con), 1% methionine (Meth), 0.5% cholesterol (Chol) or 1% methionine plus 0.5% cholesterol (MethChol).Myocardial fibrosis was not significantly increased in Chol or Meth. However, interstitial fibrosis increased by 85% (p = 0.03) and perivascular fibrosis 28-fold (p < 0.01) in the MethChol group compared to Con.These results suggest that high levels of dietary cholesterol or methionine alone do not significantly increase myocardial collagen content. However, the combination of the two diets does cause myocardial fibrosis. Therefore, excessive cholesterol and methionine intake may be an important pathogenic factor in the development of myocardial fibrosis.
Gov't Doc #: 16054151
DOI: 10.1016/j.atherosclerosis.2005.06.036
ORCID: 0000-0001-9554-6556
Journal: Atherosclerosis
PubMed URL: 16054151
Type: Journal Article
Subjects: Animals
Cholesterol, Dietary.adverse effects
Coronary Vessels.metabolism.pathology
Methionine.administration & dosage.adverse effects
Appears in Collections:Journal articles

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