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Title: Factors affecting survival in patients with oral cancer: an Australian perspective.
Austin Authors: Chandu, Arun;Adams, G;Smith, Andrew C H
Affiliation: Oral and Maxillofacial Surgery, Austin Health, Burgundy St., Heidelberg 3084, Victoria, Australia
Issue Date: 1-Jul-2005
Publication information: International Journal of Oral and Maxillofacial Surgery; 34(5): 514-20
Abstract: Little is known regarding disease-specific cumulative survival and factors affecting survival in Australian populations with oral squamous cell carcinoma. Kaplan Meier and Cox proportional hazards models were used to determine survival factors in 116 consecutive patients treated surgically at a single institution. Overall 5-year disease-specific survival rate was 83.3%. Five-year disease-specific survival probability was 88.7%, 83.8%, 83.3% and 76.5% for stage I, II, III and IV, respectively. Univariate analysis revealed that local and regional recurrence, distant metastases, N stage, margin status, radiotherapy, perivascular spread and extra-capsular spread (ECS) significantly influenced survival. Significant multivariate factors included local and regional recurrence, positive margins, and ECS. Better survival rates were found than in previous, older Australian reports. Close observation for early recurrence and aggressive management of patients with recurrence, positive margins and ECS, is advised.
Gov't Doc #: 16053871
DOI: 10.1016/j.ijom.2004.10.006
Type: Journal Article
Subjects: Adult
Aged, 80 and over
Carcinoma, Squamous Cell.mortality.pathology.secondary
Disease-Free Survival
Follow-Up Studies
Middle Aged
Mouth Neoplasms.mortality.pathology
Neoplasm Invasiveness
Neoplasm Recurrence, Local.mortality
Neoplasm Staging
Proportional Hazards Models
Radiotherapy, Adjuvant
Retrospective Studies
Sex Factors
Survival Rate
Appears in Collections:Journal articles

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