Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9795
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dc.contributor.authorFifis, Theodoraen
dc.contributor.authorGamvrellis, Anitaen
dc.contributor.authorCrimeen-Irwin, Blessingen
dc.contributor.authorPietersz, Geoffrey Aen
dc.contributor.authorLi, Jieen
dc.contributor.authorMottram, Patricia Len
dc.contributor.authorMcKenzie, Ian F Cen
dc.contributor.authorPlebanski, Magdalenaen
dc.date.accessioned2015-05-15T23:02:18Z
dc.date.available2015-05-15T23:02:18Z
dc.date.issued2004-09-01en
dc.identifier.citationJournal of Immunology (baltimore, Md. : 1950); 173(5): 3148-54en
dc.identifier.govdoc15322175en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/9795en
dc.description.abstractInfection can protect against subsequent disease by induction of both humoral and cellular immunity, but inert protein-based vaccines are not as effective. In this study, we present a new vaccine design, with Ag covalently conjugated to solid core nano-beads of narrowly defined size (0.04-0.05 microm) that localize to dendritic cells (DEC205(+) CD40(+), CD86(+)) in draining lymph nodes, inducing high levels of IFN-gamma production (CD8 T cells: precursor frequencies 1/5000 to 1/1000) and high Ab titers in mice. Conjugation of Ag to these nano-beads induced responses that were significantly higher (2- to 10-fold) than those elicited by other bead sizes, and higher than a range of currently used adjuvants (alum, QuilA, monophosphoryl lipid A). Responses were comparable to CFA/IFA immunization for Abs and ex vivo peptide-pulsed dendritic cell immunization for CD8 T cells. A single dose of Ag-conjugated beads protected mice from tumors in two different model challenges and caused rapid clearance of established tumors in mice. Thus, a range of Ags conjugated to nano-beads was effective as immunogens in both therapeutic and prophylactic scenarios.en
dc.language.isoenen
dc.subject.otherAdjuvants, Immunologic.pharmacologyen
dc.subject.otherAnimalsen
dc.subject.otherAntigens.immunologyen
dc.subject.otherCancer Vaccines.immunology.pharmacologyen
dc.subject.otherDisease Models, Animalen
dc.subject.otherMiceen
dc.subject.otherNanotechnologyen
dc.subject.otherNanotubesen
dc.subject.otherNeoplasms.drug therapy.immunology.prevention & controlen
dc.titleSize-dependent immunogenicity: therapeutic and protective properties of nano-vaccines against tumors.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Immunology (Baltimore, Md. : 1950)en
dc.identifier.affiliationAustin Research Institute, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages3148-54en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/15322175en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
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