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dc.contributor.authorBellomo, Rinaldoen
dc.contributor.authorRonco, Claudioen
dc.contributor.authorKellum, John Aen
dc.contributor.authorMehta, Ravindra Len
dc.contributor.authorPalevsky, Paulen
dc.identifier.citationCritical Care 2004; 8(4): R204-12en
dc.description.abstractThere is no consensus definition of acute renal failure (ARF) in critically ill patients. More than 30 different definitions have been used in the literature, creating much confusion and making comparisons difficult. Similarly, strong debate exists on the validity and clinical relevance of animal models of ARF; on choices of fluid management and of end-points for trials of new interventions in this field; and on how information technology can be used to assist this process. Accordingly, we sought to review the available evidence, make recommendations and delineate key questions for future studies.We undertook a systematic review of the literature using Medline and PubMed searches. We determined a list of key questions and convened a 2-day consensus conference to develop summary statements via a series of alternating breakout and plenary sessions. In these sessions, we identified supporting evidence and generated recommendations and/or directions for future research.We found sufficient consensus on 47 questions to allow the development of recommendations. Importantly, we were able to develop a consensus definition for ARF. In some cases it was also possible to issue useful consensus recommendations for future investigations. We present a summary of the findings. (Full versions of the six workgroups' findings are available on the internet at limited data, broad areas of consensus exist for the physiological and clinical principles needed to guide the development of consensus recommendations for defining ARF, selection of animal models, methods of monitoring fluid therapy, choice of physiological and clinical end-points for trials, and the possible role of information technology.en
dc.subject.otherAcute Kidney Injury.diagnosis.therapyen
dc.subject.otherCritical Illness.classificationen
dc.subject.otherFluid Therapyen
dc.subject.otherGlomerular Filtration Rateen
dc.subject.otherModels, Animalen
dc.subject.otherOutcome Assessment (Health Care)en
dc.subject.otherRandomized Controlled Trials as Topicen
dc.subject.otherRenal Replacement Therapyen
dc.subject.otherSensitivity and Specificityen
dc.titleAcute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group.en
dc.typeJournal Articleen
dc.identifier.journaltitleCritical Careen
dc.identifier.affiliationDepartment of Intensive Care and Medicine, Austin Health, Melbourne, Australiaen
dc.contributor.corpauthorAcute Dialysis Quality Initiative workgroupen
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.fulltextWith Fulltext-
item.cerifentitytypePublications- Care- Analytics Research and Evaluation (DARE) Centre-
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