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Title: Cross-priming of CD8+ T cells by viral and tumor antigens is a robust phenomenon.
Austin Authors: Chen, Weisan;Masterman, Kelly-Anne;Basta, Sameh;Haeryfar, S M Mansour;Dimopoulos, Nektaria;Knowles, Barbara;Bennink, Jack R;Yewdell, Jonathan W
Affiliation: T Cell Laboratory, Cancer Vaccine Unit, Ludwig Institute for Cancer Research, Austin & Repatriation Medical Centre, Heidelberg, Australia
Issue Date: 1-Jan-2004
Publication information: European Journal of Immunology; 34(1): 194-9
Abstract: "Cross-priming" refers to the activation of naive CD8+ T cells by antigen-presenting cells that have acquired nominal antigens from another cell. The biological relevance of cross-priming of CD8+ T cells has recently been challenged (Zinkernagel, R. M., Eur. J. Immunol. 2002. 32: 2385-2392), on the basis that responses are weak or poorly quantitated, and the determinants recognized are undefined. Here we show that cross-priming is a robust process that elicits vigorous primary responses to multiple peptides in two well-defined systems. Our findings support the relevance of cross-priming in CD8+ T cell responses to viruses and tumor cells, and demonstrate that cross-priming elicits CD8+ T cells to determinants generated by the endogenous processing pathway.
Gov't Doc #: 14971045
DOI: 10.1002/eji.200324257
Type: Journal Article
Subjects: Animals
Antigens, Neoplasm.immunology
Antigens, Polyomavirus Transforming.immunology
Antigens, Viral.immunology
CD8-Positive T-Lymphocytes.immunology
Influenza A virus.immunology
Appears in Collections:Journal articles

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