Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9658
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dc.contributor.authorGao, Xen
dc.contributor.authorPhillips, P Aen
dc.contributor.authorWiddop, Robert Een
dc.contributor.authorTrinder, Den
dc.contributor.authorJarrott, Ben
dc.contributor.authorJohnston, Colin Ien
dc.date.accessioned2015-05-15T22:50:04Z
dc.date.available2015-05-15T22:50:04Z
dc.date.issued1992-09-28en
dc.identifier.citationNeuroscience Letters; 145(1): 79-82en
dc.identifier.govdoc1461573en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9658en
dc.description.abstractThe nucleus of the solitary tract (NTS) is one of the brain regions by which arginine vasopressin (AVP) influences blood pressure. This series of experiments in adult male rats was designed to determine whether the AVP binding sites which have been demonstrated in the NTS by in vitro autoradiography might be presynaptic on vagal afferents from the nodose ganglion; whether the AVP binding sites on vagal afferent neurones are functional receptors; and whether vagal transport of AVP receptors to other organs also occurs. High affinity binding sites (using the selective V1 antagonist radioligand [125I][d(CH2)5,Sar7]AVP and in vitro autoradiography) with characteristics of V1 receptors in the medial subnucleus of the NTS were reduced by 40% ipsilateral to nodose ganglionectomy. The nodose ganglion itself also contained high affinity V1 AVP binding sites that localised over cell bodies of vagal sensory neurones. That these binding sites were functional receptors was apparent when low concentrations of AVP but not oxytocin were found to depolarize the isolated nodose ganglion utilizing the 'silicone grease gap' technique. Furthermore, the actions of AVP were antagonised by low concentrations of a selective V1 receptor antagonist. However, there was no accumulation of AVP binding sites adjacent to either the proximal or distal vagal ligations suggesting that peripheral vagal transport of AVP receptors may not occur. Therefore these results are consistent with functional AVP V1 receptors occurring in the nodose ganglion. These receptors may occur on central terminals of vagal sensory neurones in the medial subnucleus of the NTS, but there was no evidence for peripheral transport of AVP V1 receptors.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherAutoradiographyen
dc.subject.otherDensitometryen
dc.subject.otherMaleen
dc.subject.otherMedulla Oblongata.cytology.metabolismen
dc.subject.otherNeurons.metabolismen
dc.subject.otherNeurons, Afferent.metabolismen
dc.subject.otherNodose Ganglion.cytology.metabolismen
dc.subject.otherOxytocin.metabolismen
dc.subject.otherRatsen
dc.subject.otherRats, Sprague-Dawleyen
dc.subject.otherReceptors, Vasopressin.metabolismen
dc.subject.otherVagus Nerve.cytology.metabolismen
dc.titlePresence of functional vasopressin V1 receptors in rat vagal afferent neurones.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeuroscience lettersen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages79-82en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/1461573en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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