Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9564
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dc.contributor.authorSmith, I Len
dc.contributor.authorSmith, E Aen
dc.date.accessioned2015-05-15T22:42:38Z
dc.date.available2015-05-15T22:42:38Z
dc.date.issued1992-12-01en
dc.identifier.citationBlood Coagulation & Fibrinolysis : An International Journal in Haemostasis and Thrombosis; 3(6): 759-63en
dc.identifier.govdoc1336985en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9564en
dc.description.abstractVerapamil, an inhibitor of calcium channels, was shown to inhibit PAF-induced platelet activation. In the presence of 50 microM Verapamil both thromboxane (Tx) formation and release of ATP from dense granules induced by 100 nM PAF was completely inhibited. This concentration of Verapamil only produced partial inhibition of PAF-induced aggregation. It also reduced the size of the PAF-induced calcium (Ca2+) transient demonstrated in Fura-2 loaded platelets. In the absence of extracellular Ca2+, following chelation by EGTA, PAF was still able to induce a Ca2+ transient confirming the requirement of both intra and extracellular Ca2+ for PAF-induced platelet activation. 100 microM Verapamil was able to completely abolish the calcium transient induced by low doses of PAF. These results further suggest that Verapamil is able to inhibit PAF-induced platelet activation by mechanisms apart from blocking Ca2+ channels.en
dc.language.isoenen
dc.subject.otherAdenosine Triphosphate.secretionen
dc.subject.otherBlood Platelets.drug effects.secretionen
dc.subject.otherCalcium.metabolismen
dc.subject.otherCalcium Channels.drug effectsen
dc.subject.otherHumansen
dc.subject.otherPlatelet Activating Factor.antagonists & inhibitorsen
dc.subject.otherPlatelet Activation.drug effectsen
dc.subject.otherThromboxane B2.biosynthesis.secretionen
dc.subject.otherVerapamil.pharmacologyen
dc.titleInhibition of PAF-induced activation of human platelets by verapamil.en
dc.typeJournal Articleen
dc.identifier.journaltitleBlood coagulation & fibrinolysis : an international journal in haemostasis and thrombosisen
dc.identifier.affiliationDepartment of Haematology, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages759-63en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/1336985en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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