Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9558
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dc.contributor.authorMurohara, Yen
dc.contributor.authorJohnston, Colin Ien
dc.date.accessioned2015-05-15T22:42:10Z
dc.date.available2015-05-15T22:42:10Z
dc.date.issued1992-05-01en
dc.identifier.citationClinical and Experimental Pharmacology & Physiology; 19(5): 380-3en
dc.identifier.govdoc1325886en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9558en
dc.description.abstract1. The acute hormonal, renal and haemodynamic effects of SCH 39370, a new neutral endopeptidase (NEP) inhibitor, were evaluated in rats with congestive heart failure (CHF) produced by coronary ligation. 2. Left ventricular systolic pressure and left ventricular end diastolic pressure were significantly decreased by SCH 39370 treatment. 3. SCH 39370 improved cardiac function by increasing cardiac index and decreasing total peripheral resistance. 4. SCH 39370 induced a transient but significant diuresis and natriuresis. 5. These effects were associated with significant increases in urinary atrial natriuretic peptide (ANP) and cyclic GMP excretion, but not with an increase in plasma ANP levels. 6. The results suggest that NEP inhibition may be a new therapeutic method for treating CHF possibly by potentiating the biological activities of endogenous ANP.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherAtrial Natriuretic Factor.urineen
dc.subject.otherCardiac Output.drug effectsen
dc.subject.otherCyclic GMP.urineen
dc.subject.otherDipeptides.pharmacologyen
dc.subject.otherFemaleen
dc.subject.otherHeart Failure.drug therapy.enzymology.physiopathologyen
dc.subject.otherHemodynamics.drug effectsen
dc.subject.otherKidney.drug effectsen
dc.subject.otherPharmaceutical Vehicles.pharmacologyen
dc.subject.otherProtease Inhibitors.pharmacologyen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred Strainsen
dc.subject.otherVascular Resistance.drug effectsen
dc.subject.otherVentricular Function, Left.drug effectsen
dc.titleEffect of neutral endopeptidase inhibitor in rats with congestive heart failure.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical and Experimental Pharmacology & Physiologyen
dc.identifier.affiliationDepartment of Medicine, Austin Hospital, University of Melbourne, Heidelberg, Victoria, Australiaen
dc.description.pages380-3en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/1325886en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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