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Title: Effect of neutral endopeptidase inhibitor in rats with congestive heart failure.
Austin Authors: Murohara, Y;Johnston, Colin I
Affiliation: Department of Medicine, Austin Hospital, University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: 1-May-1992
Publication information: Clinical and Experimental Pharmacology & Physiology; 19(5): 380-3
Abstract: 1. The acute hormonal, renal and haemodynamic effects of SCH 39370, a new neutral endopeptidase (NEP) inhibitor, were evaluated in rats with congestive heart failure (CHF) produced by coronary ligation. 2. Left ventricular systolic pressure and left ventricular end diastolic pressure were significantly decreased by SCH 39370 treatment. 3. SCH 39370 improved cardiac function by increasing cardiac index and decreasing total peripheral resistance. 4. SCH 39370 induced a transient but significant diuresis and natriuresis. 5. These effects were associated with significant increases in urinary atrial natriuretic peptide (ANP) and cyclic GMP excretion, but not with an increase in plasma ANP levels. 6. The results suggest that NEP inhibition may be a new therapeutic method for treating CHF possibly by potentiating the biological activities of endogenous ANP.
Gov't Doc #: 1325886
Type: Journal Article
Subjects: Animals
Atrial Natriuretic Factor.urine
Cardiac Output.drug effects
Cyclic GMP.urine
Heart Failure.drug therapy.enzymology.physiopathology
Hemodynamics.drug effects
Kidney.drug effects
Pharmaceutical Vehicles.pharmacology
Protease Inhibitors.pharmacology
Rats, Inbred Strains
Vascular Resistance.drug effects
Ventricular Function, Left.drug effects
Appears in Collections:Journal articles

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