Please use this identifier to cite or link to this item:
Title: Calcium channels and their involvement in cardiovascular disease.
Austin Authors: Nayler, W G
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 9-Jan-1992
Publication information: Biochemical Pharmacology; 43(1): 39-46
Abstract: The widespread distribution of L-type Ca2+ channels in the cardiovascular system makes that system a natural 'target' for drugs which inhibit L-type Ca2+ channel activity. Now that tissue-dependent differences in the chemical composition of the calcium antagonist binding sites have been recognized it may be possible to develop drugs with enhanced tissue selectivity. The search for new compounds should not be restricted to improvements in tissue selectivity, however. Some of the ancillary properties of the L-type Ca2+ channel inhibitors--including their ability to protect against lipid peroxidation--should not be lost because these ancillary properties may contribute significantly to their usefulness as therapeutic agents.
Gov't Doc #: 1310407
Journal: Biochemical pharmacology
Type: Journal Article
Subjects: Binding Sites
Brain Ischemia.metabolism
Calcium Channel Blockers.metabolism
Calcium Channels.metabolism
Cardiovascular Diseases.drug therapy.metabolism
Drug Design
Appears in Collections:Journal articles

Show full item record

Page view(s)

checked on Apr 19, 2024

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.