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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bach, Leon A | en |
dc.date.accessioned | 2015-05-15T22:38:14Z | |
dc.date.available | 2015-05-15T22:38:14Z | |
dc.date.issued | 1992-03-01 | en |
dc.identifier.citation | Growth Regulation; 2(1): 30-9 | en |
dc.identifier.govdoc | 1283098 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/9515 | en |
dc.description.abstract | The kidney is a site of insulin-like growth factor I (IGF-I) production and IGF-I mediates effects on kidney growth and function. Diabetes is associated with kidney growth in man and the rat and, in the latter, commences within 48 h of induction of diabetes. Levels of kidney IGF-I are increased during the first 2-3 days of diabetes and this is at least partially due to increased production. Additionally, IGF-I binding is increased in diabetic rat kidney, due to increased binding to the IGF-I receptor and induction of proximal tubular binding protein expression. These changes are attenuated in prepubertal rats suggesting hormonal regulation. Further studies suggest that the changes are partly GH-dependent but independent of direct sex steroid effects. As kidney growth has been implicated in the subsequent development of diabetic nephropathy, further exploration of the close association between diabetes-related kidney growth and IGF-I accumulation may lead to an improved understanding of this complication. | en |
dc.language.iso | en | en |
dc.subject.other | Animals | en |
dc.subject.other | Carrier Proteins.physiology | en |
dc.subject.other | Cell Division.physiology | en |
dc.subject.other | Diabetes Mellitus.pathology.physiopathology | en |
dc.subject.other | Diabetic Nephropathies.physiopathology | en |
dc.subject.other | Humans | en |
dc.subject.other | Insulin-Like Growth Factor Binding Proteins | en |
dc.subject.other | Insulin-Like Growth Factor I.physiology | en |
dc.subject.other | Kidney.growth & development.pathology.physiology | en |
dc.subject.other | Rats | en |
dc.title | IGF-I and IGF binding proteins in diabetes-related kidney growth. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Growth regulation | en |
dc.identifier.affiliation | Endocrine Unit, Austin Hospital, Heidelberg, Victoria, Australia | en |
dc.description.pages | 30-9 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/1283098 | en |
dc.type.austin | Journal Article | en |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
Appears in Collections: | Journal articles |
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