Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9515
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dc.contributor.authorBach, Leon Aen
dc.date.accessioned2015-05-15T22:38:14Z
dc.date.available2015-05-15T22:38:14Z
dc.date.issued1992-03-01en
dc.identifier.citationGrowth Regulation; 2(1): 30-9en
dc.identifier.govdoc1283098en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9515en
dc.description.abstractThe kidney is a site of insulin-like growth factor I (IGF-I) production and IGF-I mediates effects on kidney growth and function. Diabetes is associated with kidney growth in man and the rat and, in the latter, commences within 48 h of induction of diabetes. Levels of kidney IGF-I are increased during the first 2-3 days of diabetes and this is at least partially due to increased production. Additionally, IGF-I binding is increased in diabetic rat kidney, due to increased binding to the IGF-I receptor and induction of proximal tubular binding protein expression. These changes are attenuated in prepubertal rats suggesting hormonal regulation. Further studies suggest that the changes are partly GH-dependent but independent of direct sex steroid effects. As kidney growth has been implicated in the subsequent development of diabetic nephropathy, further exploration of the close association between diabetes-related kidney growth and IGF-I accumulation may lead to an improved understanding of this complication.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherCarrier Proteins.physiologyen
dc.subject.otherCell Division.physiologyen
dc.subject.otherDiabetes Mellitus.pathology.physiopathologyen
dc.subject.otherDiabetic Nephropathies.physiopathologyen
dc.subject.otherHumansen
dc.subject.otherInsulin-Like Growth Factor Binding Proteinsen
dc.subject.otherInsulin-Like Growth Factor I.physiologyen
dc.subject.otherKidney.growth & development.pathology.physiologyen
dc.subject.otherRatsen
dc.titleIGF-I and IGF binding proteins in diabetes-related kidney growth.en
dc.typeJournal Articleen
dc.identifier.journaltitleGrowth regulationen
dc.identifier.affiliationEndocrine Unit, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages30-9en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/1283098en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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